ArticleNature communications2023
Ventromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Heightened empathic responses led by imbalanced cortico-amygdala circuit inbioRxiv : the preprint server for biology · 2025Article
- Orbitofrontal cortex influences dopamine dynamics associated with alloparental behavioral acquisition in female mice.Science advances · 2025Article
- Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model.Scientific reports · 2025Article
- An intracranial dissection of human escape circuits.Nature communications · 2025Article
- Cortical representations of affective pain shape empathic fear in male mice.Nature communications · 2025Article
- Article
- Understanding Others' Distress Through Past Experiences: The Role of Memory Engram Cells in Observational Fear.Advances in neurobiology · 2024Review
- Nucleus accumbens core single cell ensembles bidirectionally respond to experienced versus observed aversive events.Scientific reports · 2023Article
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Authors and funding
7 authors.
Funding
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Abstract
Perception of fear induced by others in danger elicits complex vicarious fear responses and behavioral outputs. In rodents, observing a conspecific receive aversive stimuli leads to escape and freezing behavior. It remains unclear how these behavioral self-states in response to others in fear are neurophysiologically represented. Here, we assess such representations in the ventromedial prefrontal cortex (vmPFC), an essential site for empathy, in an observational fear (OF) paradigm in male mice. We classify the observer mouse's stereotypic behaviors during OF using a machine-learning approach. Optogenetic inhibition of the vmPFC specifically disrupts OF-induced escape behavior. In vivo Ca
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