ArticleNature communications2023
Causal associations between cardiorespiratory fitness and type 2 diabetes.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
36 citing papers in PubMed, 47 citations in OpenAlex.
- Assessment of Cardiorespiratory Fitness in Individuals With Type 2 Diabetes Mellitus: Protocol for a Systematic Review and Meta-Analysis.JMIR research protocols · 2026Article
- Joint non-linear dose-response associations of device-measured physical activity and cardiorespiratory fitness with cardiovascular disease: a cohort and Mendelian randomisation study.British journal of sports medicine · 2026Article
- Aerobic Fitness and Health-Related Phenotypes: A Two-Stage Phenome-Wide Mendelian Randomization Study.Medicine and science in sports and exercise · 2026Article
- Associations of cardiorespiratory fitness with structural brain networks in ageing: insights from The Maastricht Study.GeroScience · 2026Article
- The Prognostic Impact of Cardiorespiratory Fitness on Mortality in Diabetes Patients With and Without Left Ventricular Hypertrophy.Reviews in cardiovascular medicine · 2026Article
- Observational
- Evaluation of Genetics in the Association Between Cardiorespiratory Fitness and Health: Insights from a Genome-Wide Polygenic Score for Cardiorespiratory Fitness in the FinnGen and HUNT cohorts.Scandinavian journal of medicine & science in sports · 2026Article
- Estimated Cardiorespiratory Fitness and Risk of Incident Frailty in Middle-Aged and Older Adults: A Cross-National Longitudinal Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- PeakExperimental physiology · 2026Article
- Circulating protein biomarkers of physical fitness associated with cardiometabolic risk in women after gestational diabetes: a PONCH study.Cardiovascular diabetology · 2026Article
- Fitness parameters as a marker of cardiac autonomic neuropathy among diabetes mellitus patients.Bioinformation · 2026Article
- Polygenic prediction of cardiorespiratory fitness in the Trøndelag health study (HUNT).Scientific reports · 2025Article
- Diabetes Status Modifies the Association Between Cardiorespiratory Fitness and Coronary Heart Disease: A Cross-Sectional Study.Journal of diabetes · 2025Article
- Patient Empowerment for Lifestyle Changes in Metabolic-Bariatric Surgery-A German Nationwide Survey.Obesity surgery · 2025Article
- Cardiorespiratory Fitness, Body Composition, Diabetes, and Longevity: A 2-Sample Mendelian Randomization Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Impact of cycling cadence on physiological response during a cardiopulmonary exercise test.BMJ open respiratory research · 2025Article
- Protecting the Heart in Motion: The Role of Physical Activity and Cardiorespiratory Fitness in Preventing Sudden Cardiac Death.Clinical Medicine Insights. Cardiology · 2025Review
- Exercise snacks and physical fitness in sedentary populations.Sports medicine and health science · 2025Review
- Association of sugar-sweetened beverage consumption and cardiorespiratory fitness with executive function: a cross-sectional survey based on Tajik adolescents at high altitude in China.Frontiers in public health · 2025Article
- Cardiorespiratory fitness in adolescence and risk of type 2 diabetes in late adulthood in one million Swedish men: nationwide sibling controlled cohort study.BMJ medicine · 2025Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Higher cardiorespiratory fitness is associated with lower risk of type 2 diabetes. However, the causality of this relationship and the biological mechanisms that underlie it are unclear. Here, we examine genetic determinants of cardiorespiratory fitness in 450k European-ancestry individuals in UK Biobank, by leveraging the genetic overlap between fitness measured by an exercise test and resting heart rate. We identified 160 fitness-associated loci which we validated in an independent cohort, the Fenland study. Gene-based analyses prioritised candidate genes, such as CACNA1C, SCN10A, MYH11 and MYH6, that are enriched in biological processes related to cardiac muscle development and muscle contractility. In a Mendelian Randomisation framework, we demonstrate that higher genetically predicted fitness is causally associated with lower risk of type 2 diabetes independent of adiposity. Integration with proteomic data identified N-terminal pro B-type natriuretic peptide, hepatocyte growth factor-like protein and sex hormone-binding globulin as potential mediators of this relationship. Collectively, our findings provide insights into the biological mechanisms underpinning cardiorespiratory fitness and highlight the importance of improving fitness for diabetes prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.