Evidence map›Paper›PMID 37400359›Full record

ReviewAnnals of the New York Academy of Sciences2023

Nonalcoholic liver disease: Epidemiology, risk factors, natural history, and management strategies.

George Agyapong, Farzaneh Dashti, Bubu A Banini

Registry-linked trialAbstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06588699 (Clinical Trial of Oral Digoxin In NASH), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06588699 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Clinical Trial of Oral Digoxin In NASH (CODIN)

TypeinterventionalSponsorYale UniversityRan2025 to 2029Enrolled144ConditionsNASH, NAFLD, MASH - Metabolic Dysfunction-Associated Steatohepatitis, MashArmsDigoxin, Placebo
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Nano-Enhanced Diets: Advancing Metabolic Dysfunction-Related Steatotic Liver Disease (MASLD) - A Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

George AgyapongSection of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.
Farzaneh DashtiSection of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.
Bubu A BaniniSection of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale-SCORE Resource Support CoreU54AA027989 · NIAAA · YALE UNIVERSITY · PI Sherry Ann McKee · 2020 to 2026
$13.0M
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS U54 AA027989
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is now the most common chronic liver disease worldwide and a leading indication for liver transplantation in the United States. NAFLD encompasses a heterogeneous clinicopathologic spectrum, ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis, and progressive fibrosis, which can lead to end-stage liver disease including cirrhosis and hepatocellular cancer. Predictive models suggest that over 100 million adults in the United States will have NAFLD by 2030, representing over a third of the population. In this manuscript, we provide an overview of NAFLD risk factors, natural history (including hepatic and extra-hepatic outcomes), diagnosis, and current management strategies.

Indexed as

Non-alcoholic Fatty Liver DiseaseDisease ProgressionFibrosisHumansLiverLiver CirrhosisRisk FactorsUnited Statesclinical trialsfibrosismetabolic dysfunction-associated fatty liver diseasenonalcoholic fatty liver diseasenonalcoholic steatohepatitisweight loss

Identifiers

PMID37400359
PMCPMC10524684

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.