Evidence map›Paper›PMID 37400244›Full record

ArticleNeurology2023

Expressive Prosody in Patients With Focal Anterior Temporal Neurodegeneration.

Amandine Geraudie, Peter S Pressman, Jérémie Pariente, Carly Millanski, Eleanor R Palser, Buddhika M Ratnasiri, Giovanni Battistella, Maria Luisa Mandelli, Zachary A Miller, Bruce L Miller and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Multimodal semantic knowledge of emotion concepts in frontotemporal dementia.medRxiv : the preprint server for health sciences · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 3 countries.

Amandine GeraudieFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
Peter S PressmanFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
Jérémie ParienteFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
Carly MillanskiFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
Eleanor R PalserFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
Buddhika M RatnasiriFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
Giovanni BattistellaFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
Maria Luisa MandelliFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
Zachary A MillerFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
Bruce L MillerFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
Virginia SturmFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
Katherine P RankinFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
Maria Luisa Gorno-TempiniFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
Maxime MontembeaultFrom the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada. maxime.montembeault@mcgill.ca.ORCID 0000-0002-9369-0498
Centre National de la Recherche Scientifique · FR

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
The Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Training - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4M
Primary Progressive Aphasia: Cognition, Anatomy and ProgressionRF1NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2022 to 2022
$4.7M
Attention and Semantic Evaluation as Predictors of Empathy in Healthy Aging and Frontotemporal DementiaRF1AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2019 to 2019
$4.0M
Measuring Altered Social Behavior in Neurodegenerative DiseaseR01AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2008 to 2018
$3.6M
Establishing Evidence-based Treatment for Speech and Language in Primary Progressive AphasiaR01DC016291 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI HENRY, MAYA · 2017 to 2021
$3.3M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Neuropathological basis of brain network dysfunctionK08AG052648 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPINA, SALVATORE · 2016 to 2020
$852k
NIA NIH HHS K08 AG052648NIA NIH HHS P01 AG019724NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG029577NIA NIH HHS R01 AG038791NIA NIH HHS RF1 AG029577NIDCD NIH HHS K24 DC015544NIDCD NIH HHS R01 DC016291NINDS NIH HHS R01 NS050915NINDS NIH HHS RF1 NS050915NINDS NIH HHS U54 NS092089
6 · The paper itself

Abstract

BACKGROUND AND

objectivesProgressive focal anterior temporal lobe (ATL) neurodegeneration has been historically called semantic dementia. More recently, semantic variant primary progressive aphasia (svPPA) and semantic behavioral variant frontotemporal dementia (sbvFTD) have been linked with predominant left and right ATL neurodegeneration, respectively. Nonetheless, clinical tools for an accurate diagnosis of sbvFTD are still lacking. Expressive prosody refers to the modulation of pitch, loudness, tempo, and quality of voice used to convey emotional and linguistic information and has been linked to bilateral but right-predominant frontotemporal functioning. Changes in expressive prosody can be detected with semiautomated methods and could represent a useful diagnostic marker of socioemotional functioning in sbvFTD.

methodsParticipants underwent a comprehensive neuropsychological and language evaluation and a 3T MRI at the University of California San Francisco. Each participant provided a verbal description of the picnic scene from the Western Aphasia Battery. The fundamental frequency (f0) range, an acoustic measure of pitch variability, was extracted for each participant. We compared the f0 range between groups and investigated associations with an informant-rated measure of empathy, a facial emotion labeling task, and gray matter (GM) volumes using voxel-based morphometry.

resultsTwenty-eight patients with svPPA, 18 with sbvFTD, and 18 healthy controls (HCs) were included. f0 range was significantly different across groups: patients with sbvFTD showed reduced f0 range in comparison with both patients with svPPA (mean difference of -1.4 ± 2.4 semitones; 95% CI -2.4 to -0.4]; DISCUSSION: Expressive prosody may be a useful clinical marker of sbvFTD. Reduced empathy is a core symptom in sbvFTD; the present results extend this to prosody, a core component of social interaction, at the intersection of speech and emotion. They also inform the long-standing debate on the lateralization of expressive prosody in the brain, highlighting the critical role of the right superior temporal lobe.

Indexed as

Aphasia, Primary ProgressiveFrontotemporal DementiaBrainCerebral CortexEmotionsEmpathyHumansMagnetic Resonance ImagingTemporal Lobe

Identifiers

PMID37400244
PMCPMC10449437
OpenAlexW4382933015

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