Evidence map›Paper›PMID 37399887›Full record

ArticleJournal of sport and health science2024

COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history.

Kyle A Smith, Tiffany M Zúñiga, Forrest L Baker, Helena Batatinha, Charles R Pedlar, Shane C Burgess, Michael P Gustafson, Emmanuel Katsanis, Richard J Simpson

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of sport and health science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05019456 (The Effect of Acute Exercise on the Mobilization of SARS-CoV-2 Specific T-cells), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05019456 naactive not recruitingnot on this map

The Effect of Acute Exercise on the Mobilization of SARS-CoV-2 Specific T-cells

TypeinterventionalSponsorUniversity of ArizonaRan2021 to 2025Enrolled26ConditionsCOVID-19 Respiratory Infection, InfluenzaArmsCOVID-19 Vaccine
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Kyle A SmithSchool of Nutritional Sciences and Wellness, The University of Arizona, Tucson, AZ 85721, USA.
Tiffany M ZúñigaSchool of Nutritional Sciences and Wellness, The University of Arizona, Tucson, AZ 85721, USA.
Forrest L BakerSchool of Nutritional Sciences and Wellness, The University of Arizona, Tucson, AZ 85721, USA; Department of Pediatrics, The University of Arizona, Tucson, AZ 85724, USA.
Helena BatatinhaSchool of Nutritional Sciences and Wellness, The University of Arizona, Tucson, AZ 85721, USA.
Charles R PedlarFaculty of Sport, Allied Health and Performance Science, St. Mary's University, Twickenham TW1 4SX, UK; Institute of Sport Exercise and Health, University College London, London WC1E 7HU, UK.
Shane C BurgessDepartment of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ 85721, USA; The University of Arizona Cancer Center, The University of Arizona, Tucson, AZ 85719, USA.
Michael P GustafsonLaboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, AZ 85054, USA.
Emmanuel KatsanisDepartment of Pediatrics, The University of Arizona, Tucson, AZ 85724, USA; The University of Arizona Cancer Center, The University of Arizona, Tucson, AZ 85719, USA; Department of Immunobiology, The University of Arizona, Tucson, AZ 85724, USA; Department of Medicine, The University of Arizona, Tucson, AZ 85724, USA; Department of Pathology, The University of Arizona, Tucson, AZ 85724, USA.
Richard J SimpsonSchool of Nutritional Sciences and Wellness, The University of Arizona, Tucson, AZ 85721, USA; Department of Pediatrics, The University of Arizona, Tucson, AZ 85724, USA; Department of Immunobiology, The University of Arizona, Tucson, AZ 85724, USA; Department of Medicine, The University of Arizona, Tucson, AZ 85724, USA. Electronic address: rjsimpson@arizona.edu.
University of Arizona · USMayo Clinic Hospital · USSt Mary's University Twickenham London · GBUniversity of Arizona Cancer Center

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe mobilization and redistribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific T-cells and neutralizing antibodies (nAbs) during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019 (COVID-19). We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb titers.

methodsEighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 vaccine. All major leukocyte subtypes were enumerated before, during, and after exercise by flow cytometry, and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays, T-cell receptor (TCR)-β sequencing, and SARS-CoV-2 nAb serology.

resultsCOVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded exercise. However, non-infected participants had a significantly reduced mobilization of CD4+ and CD8+ naive T-cells, as well as CD4+ central memory T-cells, after vaccination (synthetic immunity group); this was not seen after vaccination in those with prior SARS-CoV-2 infection (hybrid immunity group). Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent manner. Both groups mobilized T-cells that reacted to spike protein; however, only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid antigens. nAbs increased significantly during exercise only in the hybrid immunity group.

conclusionThese data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

Indexed as

COVID-19SARS-CoV-2COVID-19 VaccinesExerciseHumansSpike Glycoprotein, CoronavirusT-LymphocytesCOVID-19 VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Anti-viralCOVID-19Exercise immunologySARS-CoV-2T-CellsVaccine

Identifiers

PMID37399887
PMCPMC10818112
OpenAlexW4382794142

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.