Evidence map›Paper›PMID 37399447›Full record

ArticleBMJ open2023

Application of the multiphase optimisation strategy (MOST) to optimise HIV prevention targeting people on medication for opioid use disorder (MOUD) who have cognitive dysfunction: protocol for a MOST study.

Colleen B Mistler, Roman Shrestha, John Gunstad, Linda Collins, Lynn Madden, Tania Huedo-Medina, Brian Sibilio, Nicholas M Copenhaver, Michael Copenhaver

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05669534 (Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05669534 phase4recruitingnot on this map

Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

TypeinterventionalSponsorUniversity of ConnecticutRan2023 to 2027Enrolled256ConditionsHiv, Opioid Use DisorderArmscommunity-friendly health recovery program, Pre-Exposure Prophylaxis and Post-Exposure Prophylaxis
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Colleen B MistlerDepartment of Allied Health Sciences, University of Connecticut, Storrs, Connecticut, USA colleen.mistler@uconn.edu.ORCID 0000-0002-8681-0252
Roman ShresthaDepartment of Allied Health Sciences, University of Connecticut, Storrs, Connecticut, USA.
John GunstadDepartment of Psychology, Kent State University, Kent, Ohio, USA.
Linda CollinsDepartment of Social and Behavioral Science, New York University College of Global Public Health, New York, New York, USA.
Lynn MaddenDepartment of Internal Medicine-AIDS, Yale University School of Medicine, New Haven, Connecticut, USA.
Tania Huedo-MedinaDepartment of Allied Health Sciences, University of Connecticut, Storrs, Connecticut, USA.
Brian SibilioUniversity of Connecticut Institute for Collaboration on Health Intervention and Policy, Storrs, Connecticut, USA.
Nicholas M CopenhaverDepartment of Allied Health Sciences, University of Connecticut, Storrs, Connecticut, USA.
Michael CopenhaverDepartment of Allied Health Sciences, University of Connecticut, Storrs, Connecticut, USA.
University of Connecticut · USKent State University · USNew York University · USYale University · US

Funding

Research Training Program in Substance Use PreventionT32DA019426 · NIDA · YALE UNIVERSITY · PI TAMI P SULLIVAN · 2005 to 2026
$7.5M
Optimizing evidence-based HIV prevention targeting people who inject drugs on PrEPR01DA055534 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI MICHAEL COPENHAVER · 2022 to 2026
$4.3M
Optimizing HIV Prevention Among Opioid-Dependent PersonsK24DA051344 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI MICHAEL COPENHAVER · 2020 to 2026
$1.3M
Training in MHealth Prevention with MSMK01DA051346 · NIDA · YALE UNIVERSITY · PI SHRESTHA, ROMAN · 2020 to 2024
$862k
NIDA NIH HHS K01 DA051346NIDA NIH HHS K24 DA051344NIDA NIH HHS R01 DA055534NIDA NIH HHS T32 DA019426
6 · The paper itself

Abstract

introductionPeople who inject drugs (PWID) have remained a contributor to the consistent HIV incidence rates in the US for decades. Pre-exposure prophylaxis (PrEP) is a promising biomedical intervention for HIV prevention among individuals at risk for HIV infection, including PWID. However, PWID report the lowest rates of PrEP uptake and adherence among at-risk groups. Tailored HIV prevention interventions must include strategies that compensate for cognitive dysfunction among PWID. METHODS AND ANALYSIS: Using the multiphase optimisation strategy, we will be conducting a 16-condition factorial experiment to investigate the effects of four different accommodation strategy components to compensate for cognitive dysfunction among 256 PWID on medication for opioid use disorder. This innovative approach will inform optimisation of a highly effective intervention to enhance PWID's ability to process and utilise HIV prevention content to improve PrEP adherence and HIV risk reduction in a drug treatment setting. ETHICS AND DISSEMINATION: The institutional review board at the University of Connecticut approved this protocol (H22-0122) with an institutional reliance agreement with APT Foundation Inc. All participants are required to sign an informed consent form prior to engaging in any study protocols. The results of this study will be disseminated on national and international platforms through presentations at major conferences and journals. TRIAL REGISTRATION NUMBER: NCT05669534.

Indexed as

Anti-HIV AgentsCognitive DysfunctionHIV InfectionsOpioid-Related DisordersPre-Exposure ProphylaxisSubstance Abuse, IntravenousHumansAnti-HIV AgentsInfectious disease/HIVSTATISTICS & RESEARCH METHODSSubstance misuse

Identifiers

PMID37399447
PMCPMC10314648
OpenAlexW4383058484

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.