ArticleProceedings of the National Academy of Sciences of the United States of America2023
Subspace partitioning in the human prefrontal cortex resolves cognitive interference.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Article
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- Sex-biased computations underlying differential set shift performance in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- A communication subspace relays context-dependent actions from human prefrontal to motor cortex.Nature neuroscience · 2026Article
- Hierarchical Reconfiguration of Neurocognitive Task Set Representations Mediates Cognitive Flexibility.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Representational dynamics during extinction of fear memories in the human brain.Nature human behaviour · 2026Article
- Conjunctive population coding integrates sensory evidence to guide adaptive behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The effects of task similarity during representation learning in brains and neural networks.Nature communications · 2025Article
- Progressive Changes Between Thalamic Nuclei and Cortical Networks Across Stimulus-Response Learning.Human brain mapping · 2025Article
- Neural dynamics of proactive and reactive cognitive control in medial and lateral prefrontal cortex.iScience · 2025Article
- A transformation from vision to imagery in the human brain.bioRxiv : the preprint server for biology · 2025Article
- Practice reshapes the geometry and dynamics of task-tailored representations.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- An intracranial dissection of human escape circuits.Nature communications · 2025Article
- The unity/diversity framework of executive functions: behavioral and neural evidence in older adults.GeroScience · 2025Article
- Increased frontoparietal activity related to lower performance in neuropsychological assessment of working memory.NeuroImage · 2025Article
- Reactivation of previous decisions repulsively biases sensory encoding but attractively biases decision-making.PLoS biology · 2025Article
- Task structure tailors the geometry of neural representations in human lateral prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Two-dimensional neural geometry underpins hierarchical organization of sequence in human working memory.Nature human behaviour · 2025Article
- Coordinated representations for naturalistic memory encoding and retrieval in hippocampal neural subspaces.Nature communications · 2025Article
- Unraveling the neural basis of repeated moral decisions with mouse tracking and fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
The human prefrontal cortex (PFC) constitutes the structural basis underlying flexible cognitive control, where mixed-selective neural populations encode multiple task features to guide subsequent behavior. The mechanisms by which the brain simultaneously encodes multiple task-relevant variables while minimizing interference from task-irrelevant features remain unknown. Leveraging intracranial recordings from the human PFC, we first demonstrate that competition between coexisting representations of past and present task variables incurs a behavioral switch cost. Our results reveal that this interference between past and present states in the PFC is resolved through coding partitioning into distinct low-dimensional neural states; thereby strongly attenuating behavioral switch costs. In sum, these findings uncover a fundamental coding mechanism that constitutes a central building block of flexible cognitive control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.