ArticleProceedings of the National Academy of Sciences of the United States of America2023
Ancient transcriptional regulators can easily evolve new pair-wise cooperativity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains.PLoS genetics · 2026Article
- Divergence of Grainy head affects chromatin accessibility, gene expression, and embryonic viability inbioRxiv : the preprint server for biology · 2024Article
- Gene loss and cis-regulatory novelty shaped core histone gene evolution in the apiculate yeast Hanseniaspora uvarum.Genetics · 2024Article
- Neo-functionalization inRoyal Society open science · 2023Article
- Ancient transcriptional regulators can easily evolve new pair-wise cooperativity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
3 authors.
Funding
Abstract
Cells regulate gene expression by the specific binding of transcription regulators to cis-regulatory sequences. Pair-wise cooperativity between regulators-whereby two different regulators physically interact and bind DNA in a cooperative manner-is common and permits complex modes of gene regulation. Over evolutionary timescales, the formation of new combinations of regulators represents a major source of phenotypic novelty, facilitating new network structures. How functional, pair-wise cooperative interactions arise between regulators is poorly understood, despite the abundance of examples in extant species. Here, we explore a protein-protein interaction between two ancient transcriptional regulators-the homeodomain protein Matα2 and the MADS box protein Mcm1-that was gained approximately 200 million y ago in a clade of ascomycete yeasts that includes
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