Evidence map›Paper›PMID 37399095›Full record

ArticleJournal of the National Cancer Institute2023

Cumulative incidence of anal cancer since HIV or AIDS diagnosis in the United States.

Cameron B Haas, Eric A Engels, Marie-Josèphe Horner, Ruth M Pfeiffer, Qianlai Luo, Aimée R Kreimer, Joel M Palefsky, Meredith S Shiels

Open access · hybridAbstract read
In one paragraph

Article in Journal of the National Cancer Institute, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. An overview of clinical trials in anal cancer 1999-2024.ESMO gastrointestinal oncology · 2026
    Article
  5. Article
  6. Review
  7. Clinical Predictors and Outcomes of Invasive Anal Cancer for People With HIV in an Inception Cohort.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cameron B HaasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-8211-0806
Eric A EngelsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Marie-Josèphe HornerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Ruth M PfeifferDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Qianlai LuoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Aimée R KreimerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Joel M PalefskyDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5097-3818
Meredith S ShielsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-8390-6091
National Cancer Institute · USUniversity of California, San Francisco · US

Funding

Studies of HIV infection and its contribution to the natural history and outcomeZIACP101235 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ENGELS, ERIC A · 2021 to 2025
$12.6M
CCR NIH HHS HHSN261201300011CHHSNCCDPHP CDC HHS 17NU58DP006334NCCDPHP CDC HHS 1NU58DP006281NCCDPHP CDC HHS 6NU58/DP006309NCCDPHP CDC HHS NU58/DP003931-05-00NCCDPHP CDC HHS NU58DP006271-04-00NCCDPHP CDC HHS NU58DP006308-04-00NCCDPHP CDC HHS NU58DP006332-03-00NCCDPHP CDC HHS NU58DP006333NCCDPHP CDC HHS NU58DP006347-01NCCDPHP CDC HHS U58 DP003875NCHHSTP CDC HHS NU62PS003960NCHHSTP CDC HHS NU62PS924522-02-00NCHHSTP CDC HHS NU62PS924536NCHHSTP CDC HHS NU62PS924546-02-00NCHHSTP CDC HHS PS18-1802NCHHSTP CDC HHS U62 PS001005NCHHSTP CDC HHS U62PS004001-2)NCHHSTP CDC HHS U62 PS004011NCI NIH HHS HHSN261201000057INCI NIH HHS HHSN261201300019INCI NIH HHS HHSN261201800008LNCI NIH HHS HHSN261201800009INCIPC CDC HHS HHSN26100002NCIPC CDC HHS N01-PC-2013-00021
6 · The paper itself

Abstract

Treatment of screen-detected anal high-grade squamous intraepithelial lesions has been shown to effectively reduce the incidence of invasive anal cancer in people with HIV. We provide population-based estimates of cumulative incidence of anal cancer by risk group and age at HIV or AIDS diagnosis. The 0- to 10-year cumulative incidence of anal cancer for men who have sex with men and are younger than 30 years of age at HIV diagnosis was 0.17% (95% confidence interval [CI] = 0.13% to 0.20%) compared with 0.04% (95% CI = 0.02% to 0.06%) in other men and 0.03% (95% CI = 0.01% to 0.04%) in women. For men who have sex with men and have a diagnosis of AIDS and are younger than 30 years of age, the 0- to 10-year cumulative incidence was 0.35% (95% CI = 0.28% to 0.41%). Among people with HIV, men who have sex with men are at the greatest risk of anal cancer, and those with a diagnosis of AIDS had higher risk than those without AIDS. These estimates may inform recommendations for priority populations that could benefit most from anal cancer screening and treatment.

Indexed as

Acquired Immunodeficiency SyndromeAnus NeoplasmsHIV InfectionsAdultAgedFemaleHomosexuality, MaleHumansIncidenceMaleMiddle AgedRisk FactorsUnited StatesYoung Adult

Identifiers

PMID37399095
PMCPMC10560593
OpenAlexW4382931031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.