ArticleJournal of the National Cancer Institute2023
Effect of treatment interruptions on overall survival in patients with triple-negative breast cancer.
Article in Journal of the National Cancer Institute, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Oncological and Survival Endpoints in Cancer Cachexia Clinical Trials: Systematic Review 6 of the Cachexia Endpoints Series.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
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- Determining acceptable duration for chemoradiation of esophageal squamous cell carcinoma.Journal of the Chinese Medical Association : JCMA · 2026Article
- Infectious Complications in Patients Receiving Superselective Intra-Arterial Chemoradiotherapy for Oral Squamous Cell Carcinoma.Oral diseases · 2026Article
- Time toxicity in CBCT-guided radiation therapy: A retrospective analysis of unplanned imaging burden across disease sites.Technical innovations & patient support in radiation oncology · 2026Article
- An international cohort study of breast cancer survival in young women.BJC reports · 2026Article
- Leveraging Centralized Health System Data Management and Large Language Model-Based Data Preprocessing to Identify Predictors for Radiation Therapy Interruption.JCO clinical cancer informatics · 2025Article
- The Role of Advanced Practice Providers in Radiation Oncology in 2025.Clinical journal of oncology nursing · 2025Article
- Quantifying and addressing self-defined needs in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Impact of treatment time and waiting time on outcome for esophageal squamous cell carcinoma receiving definitive chemoradiotherapy.Radiation oncology (London, England) · 2025Article
- Propofol Total Intravenous Anesthesia for Pediatric Proton Radiotherapy and Its Effect on Patient Outcomes.Cancers · 2025Article
- Factors Associated With Early Discontinuation of Radiation Therapy: An Analysis of the National Cancer Database.Advances in radiation oncology · 2025Article
- Analysis of reasons and risk factors for non-completion of radiotherapy courses in patients with tumors.Frontiers in oncology · 2025Article
- Treatment Outcomes after Postoperative Radiotherapy in Triple-Negative Breast Cancer: Multi-Institutional Retrospective Study (KROG 17-05).Journal of personalized medicine · 2024Article
- Radiation Therapy Delivery During the 2023 Israel-Hamas War: Trust Prevails Over Fear.Advances in radiation oncology · 2024Article
- Up-front Hypofractionated Radiotherapy Before Third-Generation Chemotherapy in Node-positive Breast Cancer: A Retrospective Comparative Study.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionCurrently, there are no data regarding the impact of treatment interruptions during radiotherapy for breast cancer. In this study, we examine the correlation between treatment interruptions during radiotherapy and outcomes in triple-negative breast cancer patients.
methodsA total of 35 845 patients with triple-negative breast cancer treated between 2010 and 2014 were identified and analyzed from the National Cancer Database. The number of interrupted radiotherapy treatment days was calculated as the difference between the total elapsed days from the start to end of radiation treatment (both initial treatment and boost treatment, when boost was administered) and the total number of expected treatment days, defined as the number of expected treatment days with an addition of 2 weekend days for every multiple of 5 treatment days. Binomial multivariate regression analysis was used to detect correlates of treatment interruptions, and propensity-score matched multivariable Cox proportional hazard models were used to evaluate the association between treatment interruption and overall survival (OS).
resultsWhen modeled as a continuous variable, longer treatment duration was associated with poorer OS (hazard ratio [HR] = 1.023, 95% confidence interval [CI] = 1.015 to 1.031). In reference to 0-1 days of interruption, patients with 2-5 interrupted days (HR = 1.069, 95% CI = 1.002 to 1.140 interrupted days), 6-10 interrupted days (HR = 1.239, 95% CI = 1.140 to 1.348 interrupted days), and 11-15 interrupted days (HR = 1.265, 95% CI = 1.126 to 1.431 interrupted days) experienced increasing likelihood of mortality.
conclusionIn the first study of its kind, we report a correlation between treatment interruptions during adjuvant radiotherapy in triple-negative breast cancer and OS.
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