Evidence map›Paper›PMID 37398895›Full record

ArticleOptica2022

Quantum-enhanced stimulated Brillouin scattering spectroscopy and imaging.

Tian Li, Fu Li, Xinghua Liu, Vladislav V Yakovlev, Girish S Agarwal

Abstract read
In one paragraph

Article in Optica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Quantum-enhanced coherent Raman spectroscopy with broadband squeezed-light detection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Harnessing quantum light for microscopic biomechanical imaging of cells and tissues.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Brillouin microscopy.Nature reviews. Methods primers · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tian LiInstitute for Quantum Science and Engineering, Texas A&M University, College Station, Texas 77843, USA.ORCID 0000-0003-2993-0386
Fu LiInstitute for Quantum Science and Engineering, Texas A&M University, College Station, Texas 77843, USA.
Xinghua LiuInstitute for Quantum Science and Engineering, Texas A&M University, College Station, Texas 77843, USA.
Vladislav V YakovlevDepartment of Physics and Astronomy, Texas A&M University, College Station, Texas 77843, USA.ORCID 0000-0002-4557-1013
Girish S AgarwalInstitute for Quantum Science and Engineering, Texas A&M University, College Station, Texas 77843, USA.

Funding

Brillouin Microscope for Biomedical ResearchR01GM127696 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI YAKOVLEV, VLADISLAV V. · 2018 to 2021
$1.1M
Molecular and cellular imaging of bone biopsies using AI augmented deep UV Raman microscopyR21CA269099 · NCI · TEXAS ENGINEERING EXPERIMENT STATION · PI BEREZIN, MIKHAIL Y., YAKOVLEV, VLADISLAV V. · 2022 to 2024
$577k
Sensing local nano-environment with coherent Raman microspectroscopyR21GM142107 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI YAKOVLEV, VLADISLAV V. · 2021 to 2022
$399k
NCI NIH HHS R21 CA269099NIGMS NIH HHS R01 GM127696NIGMS NIH HHS R21 GM142107
6 · The paper itself

Abstract

Brillouin microscopy is an emerging label-free imaging technique used to assess local viscoelastic properties. Quantum-enhanced stimulated Brillouin scattering is demonstrated using low power continuous-wave lasers at 795 nm. A signal-to-noise ratio enhancement of 3.4 dB is reported by using two-mode intensity-difference squeezed light generated with the four-wave mixing process in atomic rubidium vapor. The low optical power and the excitation wavelengths in the water transparency window have the potential to provide a powerful bio-imaging technique for probing mechanical properties of biological samples prone to phototoxicity and thermal effects. The performance enhancement affordable through the use of quantum light may pave the way for significantly improved sensitivity that cannot be achieved classically. The proposed method for utilizing squeezed light for enhanced stimulated Brillouin scattering can be easily adapted for both spectroscopic and imaging applications in biology.

Identifiers

PMID37398895
PMCPMC10312138

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.