Evidence map›Paper›PMID 37398883›Full record

ArticleWorld journal of gastroenterology2023

SGK3 overexpression correlates with a poor prognosis in endoscopically resected superficial esophageal squamous cell neoplasia: A long-term study.

Ning Xu, Long-Song Li, Hui Li, Li-Hua Zhang, Nan Zhang, Peng-Ju Wang, Ya-Xuan Cheng, Jing-Yuan Xiang, En-Qiang Linghu, Ning-Li Chai

Open access · hybridAbstract read
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In one paragraph

Article in World journal of gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ning XuSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
Long-Song LiSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
Hui LiDepartment of Gastroenterology, Air Force Medical Center, Beijing 100142, China.
Li-Hua ZhangDepartment of Pathology, The Fourth Medical Center of PLA General Hospital, Beijing 100142, China.
Nan ZhangSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
Peng-Ju WangSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
Ya-Xuan ChengSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
Jing-Yuan XiangSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
En-Qiang LinghuSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
Ning-Li ChaiSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China. chainingli@vip.163.com.
Chinese PLA General Hospital · CNAir Force General Hospital PLA · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe expression status of serum and glucocorticoid-induced protein kinase 3 (SGK3) in superficial esophageal squamous cell neoplasia (ESCN) remains unknown.

aimTo evaluate the SGK3 overexpression rate in ESCN and its influence on the prognosis and outcomes of patients with endoscopic resection.

methodsA total of 92 patients who had undergone endoscopic resection for ESCN with more than 8 years of follow-up were enrolled. Immunohistochemistry was used to evaluate SGK3 expression.

resultsSGK3 was overexpressed in 55 (59.8%) patients with ESCN. SGK3 overexpression showed a significant correlation with death (

conclusionSGK3 overexpression was detected in the majority of patients with endoscopically resected ESCN and was significantly associated with shortened survival. Thus, it might be a new prognostic factor for ESCN.

Indexed as

Carcinoma, Squamous CellEsophageal NeoplasmsEpithelial CellsHumansPrognosisProtein Serine-Threonine KinasesRetrospective StudiesSerum-Glucocorticoid Regulated KinasesProtein Serine-Threonine KinasesSerum-Glucocorticoid Regulated KinasesSGK3 protein, humanEndoscopic submucosal dissectionImmunohistochemistryOverall survivalSerum and glucocorticoid-induced protein kinaseSuperficial esophageal squamous cell neoplasia

Identifiers

PMID37398883
PMCPMC10311610
OpenAlexW4380768811

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.