Evidence map›Paper›PMID 37398820›Full record

ArticleCureus2023

Hemolytic Anemia in the Setting of Atypical Pneumonia: A Case of Cold Agglutinin Disease.

Abdelwahab Jalal Eldin, Roshni Thomas, Gary Gibson, Davis Abongwa, Israa Hassan, Mpey K Tabot Tabot, Gagan Singh, Ravi Sarma

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abdelwahab Jalal EldinInternal Medicine, Howard University Hospital, Washington, D.C., USA.
Roshni ThomasInternal Medicine, Howard University Hospital, Washington, D.C., USA.
Gary GibsonInternal Medicine, Howard University Hospital, Washington, D.C., USA.
Davis AbongwaInternal Medicine, Howard University Hospital, Washington, D.C., USA.
Israa HassanInternal Medicine, Howard University Hospital, Washington, D.C., USA.
Mpey K Tabot TabotInternal Medicine, Howard University Hospital, Washington, D.C., USA.
Gagan SinghInternal Medicine, Howard University Hospital, Washington, D.C., USA.
Ravi SarmaHematology and Medical Oncology, Howard University Hospital, Washington, D.C., USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cold agglutinin hemolytic anemia (cAHA) is a rare autoimmune disorder characterized by the production of cold agglutinins. We present a case of secondary cAHA in a 23-year-old female with severe anemia and unexplained hemolysis. The patient exhibited findings indicative of hemolysis and a positive direct antiglobulin test (DAT) with complement alone. Additional investigations revealed incidental lung infiltrates, negative serology for infections and autoimmune diseases, and a low cold agglutinin titer. The patient showed a favorable response to doxycycline and supportive therapy, including multiple packed red blood cell transfusions. At the two-week follow-up, the patient had a stable hemoglobin level with no evidence of ongoing hemolysis. This case highlights the importance of considering secondary cAHA in patients with cold symptoms or unexplained hemolysis. Primary cAHA patients may require more aggressive treatment, including rituximab and sutilumab.

Indexed as

autoimmune hemolytic anaemiacold agglutinincold agglutinin syndromeimmune hemolytic anemiasevere anemia

Identifiers

PMID37398820
PMCPMC10310400

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.