Evidence map›Paper›PMID 37398569›Full record

ArticleToxicological research2023

A comparative study on the implementation of deep learning algorithms for detection of hepatic necrosis in toxicity studies.

Ji-Hee Hwang, Minyoung Lim, Gyeongjin Han, Heejin Park, Yong-Bum Kim, Jinseok Park, Sang-Yeop Jun, Jaeku Lee, Jae-Woo Cho

Abstract read
In one paragraph

Article in Toxicological research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Deep Learning-based Modeling for Preclinical Drug Safety Assessment.bioRxiv : the preprint server for biology · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ji-Hee HwangToxicologic Pathology Research Group, Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon, 34114 Republic of Korea.
Minyoung LimToxicologic Pathology Research Group, Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon, 34114 Republic of Korea.
Gyeongjin HanToxicologic Pathology Research Group, Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon, 34114 Republic of Korea.
Heejin ParkToxicologic Pathology Research Group, Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon, 34114 Republic of Korea.
Yong-Bum KimDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon, 34114 Republic of Korea.
Jinseok ParkResearch & Development Team, LAC Inc, Seoul, 07807 Republic of Korea.
Sang-Yeop JunResearch & Development Team, LAC Inc, Seoul, 07807 Republic of Korea.
Jaeku LeeResearch & Development Team, LAC Inc, Seoul, 07807 Republic of Korea.
Jae-Woo ChoToxicologic Pathology Research Group, Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon, 34114 Republic of Korea.ORCID 0000-0003-0072-7827

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep learning has recently become one of the most popular methods of image analysis. In non-clinical studies, several tissue slides are generated to investigate the toxicity of a test compound. These are converted into digital image data using a slide scanner, which is then studied by researchers to investigate abnormalities, and the deep learning method has been started to adopt in this study. However, comparative studies evaluating different deep learning algorithms for analyzing abnormal lesions are scarce. In this study, we applied three algorithms, SSD, Mask R-CNN, and DeepLabV3 Supplementary Information: The online version contains supplementary material available at 10.1007/s43188-023-00173-5.

Indexed as

Deep learningHepatic necrosisHistopathologyImage analysisToxicology

Identifiers

PMID37398569
PMCPMC10313597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.