Evidence map›Paper›PMID 37398501›Full record

ArticlebioRxiv : the preprint server for biology2023

Demographic inference for spatially heterogeneous populations using long shared haplotypes.

Raphaël Forien, Harald Ringbauer, Graham Coop

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Raphaël ForienINRAE - BioSP, Centre INRAE PACA, 228 route de l'aérodrome, Domaine St-Paul - Site Agroparc, 84914, Avignon Cedex 9, France.
Harald RingbauerDepartment of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany.
Graham CoopCenter for Population Biology, Department of Evolution and Ecology, University of California, 2320 Storer Hall, CA 95616, Davis, United States.

Funding

The impact of natural selection and population structure on human genomic variationR35GM136290 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Graham Coop · 2020 to 2026
$2.6M
NIGMS NIH HHS R35 GM136290
6 · The paper itself

Abstract

We introduce a modified spatial Λ-Fleming-Viot process to model the ancestry of individuals in a population occupying a continuous spatial habitat divided into two areas by a sharp discontinuity of the dispersal rate and effective population density. We derive an analytical formula for the expected number of shared haplotype segments between two individuals depending on their sampling locations. This formula involves the transition density of a skew diffusion which appears as a scaling limit of the ancestral lineages of individuals in this model. We then show that this formula can be used to infer the dispersal parameters and the effective population density of both regions, using a composite likelihood approach, and we demonstrate the efficiency of this method on a range of simulated data sets.

Indexed as

isolation by distancepopulation geneticssegments of shared haplotypesskew Brownian motionspatial coalescentspatial Λ-Fleming-Viot process

Identifiers

PMID37398501
PMCPMC10312651

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.