Evidence map›Paper›PMID 37398468›Full record

ArticlebioRxiv : the preprint server for biology2023

Alterations in the Mammary Gland and Tumor Microenvironment of Formerly Obese Mice.

Genevra Kuziel, Brittney N Moore, Grace P Haugstad, Yue Xiong, Abbey E Williams, Lisa M Arendt

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Genevra KuzielCancer Biology Program, University of Wisconsin-Madison, Madison WI 53705, U.S.A.
Brittney N MooreDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison WI 53706, U.S.A.
Grace P HaugstadDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison WI 53706, U.S.A.
Yue XiongDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison WI 53706, U.S.A.
Abbey E WilliamsComparative Biomedical Sciences Program, University of Wisconsin-Madison, Madison WI 53706, U.S.A.
Lisa M ArendtCancer Biology Program, University of Wisconsin-Madison, Madison WI 53705, U.S.A.
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
PQ2 Obesity-induced fibrocytes promote breast cancer progressionR01CA227542 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ARENDT, LISA M · 2018 to 2022
$1.7M
Fibrocytes: A novel cell population promoting obesity-induced breast tumor desmoplasiaF31CA247265 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KUZIEL, GENEVRA MARIE · 2020 to 2022
$104k
NCI NIH HHS F31 CA247265NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA227542
6 · The paper itself

Abstract

Obesity is a risk factor for breast cancer, and women with obesity that develop breast cancer have a worsened prognosis. Within the mammary gland, obesity causes chronic, macrophage-driven inflammation and adipose tissue fibrosis. To examine the impact of weight loss on the mammary microenvironment, mice were fed high-fat diet to induce obesity, then switched to a low-fat diet. In formerly obese mice, we observed reduced numbers of crown-like structures and fibrocytes in mammary glands, while collagen deposition was not resolved with weight loss. Following transplant of TC2 tumor cells into the mammary glands of lean, obese, and formerly obese mice, diminished collagen deposition and cancer-associated fibroblasts were observed in tumors from formerly obese mice compared to obese mice. When TC2 tumor cells were mixed with CD11b

Indexed as

breast cancercollagenfibrocytesfibrosismacrophagesmammary glandmyeloid progenitor cellsobesityweight loss

Identifiers

PMID37398468
PMCPMC10312750
OpenAlexW4380607914

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.