ArticlebioRxiv : the preprint server for biology2023
Intrinsic Homeostatic Plasticity in Mouse and Human Sensory Neurons.
Lisa A McIlvried, John Smith Del Rosario, Melanie Y Pullen, Andi Wangzhou, Tayler D Sheahan, Andrew J Shepherd, Richard A Slivicki, John A Lemen, Theodore J Price, Bryan A Copits and 1 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors at 3 institutions in 1 country.
Lisa A McIlvriedWashington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA.
John Smith Del RosarioWashington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA.
Melanie Y PullenWashington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA.
Andi WangzhouDepartment of Neuroscience and Center for Advanced Pain Studies; The University of Texas at Dallas; Dallas, TX, 75080; USA.
Tayler D SheahanWashington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA.
Andrew J ShepherdWashington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA.
Richard A SlivickiWashington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA.
John A LemenMid-American Transplant; St. Louis, MO, 63110; USA.
Theodore J PriceDepartment of Neuroscience and Center for Advanced Pain Studies; The University of Texas at Dallas; Dallas, TX, 75080; USA.
Bryan A CopitsWashington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA.
Robert W GereauWashington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA.
Washington University in St. Louis · USThe University of Texas at Dallas · USAmerican College of Radiology · US
Funding
Multi-omics peripheral nerve atlas enables fine-mapping of pain molecular phenotypesU19NS130607 · NINDS · WASHINGTON UNIVERSITY · PI Sheng Chih Jin · 2022 to 2026
$14.0MMechanistic underpinnings of chronic low back painU19NS130608 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI Michele Curatolo, Patrick M Dougherty · 2022 to 2026
$13.6MBIOMEDICAL RESEARCH TRAINING IN DRUG ABUSET32DA007261 · NIDA · WASHINGTON UNIVERSITY · PI ARPANA AGRAWAL, Jose A Moron-Concepcion · 1991 to 2026
$8.8MTranslation Control of Pain PlasticityR01NS065926 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI PRICE, THEODORE J. · 2010 to 2023
$5.7MMECHANISMS OF PERIPHERAL MGLUR MODULATION OF NOCICEPTIONR01NS042595 · NINDS · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W · 2002 to 2017
$5.2MHomeostatic Regulatory Mechanisms in NociceptorsK00NS113422 · NINDS · WASHINGTON UNIVERSITY · PI DEL ROSARIO, JOHN SMITH · 2021 to 2024
$349kRegulation of Piezo2 Channels by G-protein Coupled Receptors and EndocytosisF99NS113422 · NINDS · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DEL ROSARIO, JOHN SMITH · 2019 to 2020
$50kNIDA NIH HHS T32 DA007261NINDS NIH HHS F99 NS113422NINDS NIH HHS K00 NS113422NINDS NIH HHS L70 NS129038NINDS NIH HHS R01 NS042595NINDS NIH HHS R01 NS065926NINDS NIH HHS U19 NS130607NINDS NIH HHS U19 NS130608
6 · The paper itselfAbstract
In response to changes in activity induced by environmental cues, neurons in the central nervous system undergo homeostatic plasticity to sustain overall network function during abrupt changes in synaptic strengths. Homeostatic plasticity involves changes in synaptic scaling and regulation of intrinsic excitability. Increases in spontaneous firing and excitability of sensory neurons are evident in some forms of chronic pain in animal models and human patients. However, whether mechanisms of homeostatic plasticity are engaged in sensory neurons under normal conditions or altered after chronic pain is unknown. Here, we showed that sustained depolarization induced by 30mM KCl induces a compensatory decrease in the excitability in mouse and human sensory neurons. Moreover, voltage-gated sodium currents are robustly reduced in mouse sensory neurons contributing to the overall decrease in neuronal excitability. Decreased efficacy of these homeostatic mechanisms could potentially contribute to the development of the pathophysiology of chronic pain.
Indexed as
DepolarizationExcitabilityHomeostatic PlasticitySensory neuronsvoltage-gated sodium channels
Identifiers
PMID37398430
PMCPMC10312743
OpenAlexW4380610383
What OpenQuestion holds
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LicenceCC BY-NC-ND
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