Evidence map›Paper›PMID 37398388›Full record

ArticlebioRxiv : the preprint server for biology2023

Targeting host sialic acids in the upper respiratory tract with a broadly-acting neuraminidase to inhibit influenza virus transmission.

Mila B Ortigoza, Catherina L Mobini, Hedy L Rocha, Stacey Bartlett, Cynthia A Loomis, Jeffrey N Weiser

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mila B OrtigozaDepartment of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, New York, USA.
Catherina L MobiniDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
Hedy L RochaDepartment of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, New York, USA.
Stacey BartlettDepartment of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, New York, USA.
Cynthia A LoomisDepartment of Pathology, New York University School of Medicine, New York, New York, USA.
Jeffrey N WeiserDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
New York University · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Richard Lewis Possemato · 1985 to 2026
$83.1M
ROLE OF OPACITY VARIATION IN PNEUMOCOCCAL PATHOGENESISR01AI038446 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WEISER, JEFFREY NEAL · 1996 to 2019
$7.4M
Mechanisms of Pneumococcal Persistence During CarriageR37AI038446 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jeffrey Neal Weiser · 2020 to 2026
$3.8M
Targeting Pneumococcal TransmissionR01AI150893 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 2020 to 2024
$3.3M
Biology of Influenza Virus TransmissionK08AI141759 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ORTIGOZA, MILA BRUM · 2019 to 2023
$939k
Multispectral imaging & analysis of intact tissue sections w/ the Perkin Elmer VectraS10OD021747 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LOOMIS, CYNTHIA A · 2016 to 2016
$359k
NCI NIH HHS P30 CA016087NIAID NIH HHS K08 AI141759NIAID NIH HHS R01 AI038446NIAID NIH HHS R01 AI150893NIAID NIH HHS R37 AI038446NIH HHS S10 OD021747
6 · The paper itself

Abstract

The ongoing transmission of influenza A viruses (IAV) for the past century continues to be a burden to humans. IAV binds terminal sialic acids (SA) of sugar molecules present within the upper respiratory tract (URT) in order to successfully infect hosts. The two most common SA structures that are important for IAV infection are those with α2,3- and α2,6-linkages. While mice were once considered to be an unsuitable system for studying IAV transmission due to their lack of α2,6-SA in the trachea, we have successfully demonstrated that IAV transmission in infant mice is remarkably efficient. This finding led us to reevaluate the SA composition of the URT of mice using

Identifiers

PMID37398388
PMCPMC10312619
OpenAlexW4379285381

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.