ArticlebioRxiv : the preprint server for biology2023
NG2 Glia Reprogramming Induces Robust Axonal Regeneration After Spinal Cord Injury.
Wenjiao Tai, Xiaolong Du, Chen Chen, Xiao-Ming Xu, Chun-Li Zhang, Wei Wu
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
6 authors at 2 institutions in 1 country.
Wenjiao TaiDepartment of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Xiaolong DuDepartment of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Chen ChenDepartment of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Xiao-Ming XuDepartment of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Chun-Li ZhangDepartment of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Wei WuDepartment of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Neurological Surgery · USThe University of Texas Southwestern Medical Center · US
Funding
Reprogramming reactive glial cells into functional new neurons after SCIR01NS111776 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI WU, WEI, ZHANG, CHUN-LI · 2020 to 2024
$2.4MInduced Adult Neurogenesis for Parkinson's DiseaseR01NS092616 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, CHUN-LI · 2016 to 2020
$2.4MIn Vivo Reprogramming of NG2 Glia for NeurogenesisR01NS117065 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, CHUN-LI · 2020 to 2024
$2.1MModulation of lumbar motor circuitry after an above-level SCI and NT-3 gene therapyR01NS103481 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI SMITH, GEORGE M, WU, WEI · 2017 to 2021
$1.9MChemical Reprogramming of Traumatic Brain InjuryR01NS099073 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, CHUN-LI · 2017 to 2021
$1.8MIn Vivo Reprogramming of Glial Fate for Spinal Cord RepairR01NS088095 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, CHUN-LI · 2014 to 2018
$1.7MNINDS NIH HHS R01 NS088095NINDS NIH HHS R01 NS092616NINDS NIH HHS R01 NS099073NINDS NIH HHS R01 NS103481NINDS NIH HHS R01 NS111776NINDS NIH HHS R01 NS117065
6 · The paper itselfAbstract
Spinal cord injury (SCI) often leads to neuronal loss, axonal degeneration and behavioral dysfunction. We recently show that in vivo reprogramming of NG2 glia produces new neurons, reduces glial scaring, and ultimately leads to improved function after SCI. By examining endogenous neurons, we here unexpectedly uncover that NG2 glia reprogramming also induces robust axonal regeneration of the corticospinal tract and serotonergic neurons. Such reprogramming-induced axonal regeneration may contribute to the reconstruction of neural networks essential for behavioral recovery.
Indexed as
5-HT axonsaxon regenerationcorticospinal tractin vivo reprogrammingNG2 gliaspinal cord injury
Identifiers
PMID37398355
PMCPMC10312714
OpenAlexW4380786062
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