Evidence map›Paper›PMID 37398341›Full record

ArticleResearch square2023

miR-31-mediated local translation at the mitotic spindle is important for early development.

Carolyn M Remsburg, Kalin Konrad, Nadezda Stepicheva, Michael Testa, Kelvin Lee, Leila Choe, Shawn Polson, Jaysheel Bhavsar, Hongzhan Huang, Jia L Song

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Carolyn M RemsburgDepartment of Biological Sciences, University of Delaware, Newark, DE 19716.
Kalin KonradDepartment of Biological Sciences, University of Delaware, Newark, DE 19716.
Nadezda StepichevaDepartment of Biological Sciences, University of Delaware, Newark, DE 19716.
Michael TestaDepartment of Biological Sciences, University of Delaware, Newark, DE 19716.
Kelvin LeeDepartment of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716.ORCID 0000-0003-0908-2981
Leila ChoeNational Institute for Innovation in Manufacturing Biopharmaceuticals, Newark, DE 19716.
Shawn PolsonDepartment of Computer and Informational Sciences; Plant & Soil Sciences; Biological Sciences, CBCB Bioinformatics Core Facility; Bioinformatics, Healthcare Informatics, and Data Science Network of Delaware, University of Delaware, Newark, DE 19716.
Jaysheel BhavsarDepartment of Computer and Informational Sciences, University of Delaware, DE 19716.
Hongzhan HuangDepartment of Computer and Informational Sciences, University of Delaware, DE 19716.
Jia L SongDepartment of Biological Sciences, University of Delaware, Newark, DE 19716.
University of Delaware · USColumbia University · USPittsburg State University · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
Updated confocal microscope in the Imaging Core facility to support biomedical researchP20GM103653 · NIGMS · DELAWARE STATE UNIVERSITY · PI HARRINGTON, MELISSA A · 2012 to 2022
$22.7M
NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM103653
6 · The paper itself

Abstract

miR-31 is a highly conserved microRNA that plays critical roles in cell proliferation, migration, and differentiation. We discovered miR-31 and some of its validated targets are enriched on the mitotic spindle of the dividing sea urchin embryo and mammalian cells. Using the sea urchin embryo, we found that miR-31 inhibition led to developmental delay correlated with increased cytoskeleton and chromosomal defects. We identified miR-31 to directly suppress several actin remodeling transcripts,

Identifiers

PMID37398341
PMCPMC10312921
OpenAlexW4380624363

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.