Evidence map›Paper›PMID 37398332›Full record

ArticlebioRxiv : the preprint server for biology2023

Mapping the architecture of the initiating phosphoglycosyl transferase from

Greg J Dodge, Alyssa J Anderson, Yi He, Weijing Liu, Rosa Viner, Barbara Imperiali

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Greg J DodgeDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-6555-8350
Alyssa J AndersonDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-4871-4283
Yi HeThermo Fisher Scientific, San Jose CA 95134, USA.ORCID 0000-0002-5565-5579
Weijing LiuThermo Fisher Scientific, San Jose CA 95134, USA.ORCID 0000-0003-2322-0500
Rosa VinerThermo Fisher Scientific, San Jose CA 95134, USA.ORCID 0000-0003-0550-5545
Barbara ImperialiDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-5749-7869
Massachusetts Institute of Technology · USThermo Fisher Scientific (United States) · US

Funding

SPECIFICITY IN CO- AND POST-TRANSLATIONAL MODIFICATIONR01GM039334 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ALLEN, KAREN N., IMPERIALI, BARBARA · 1993 to 2025
$8.0M
Structure and function of the monotopic phosphoglycosyl transferase superfamily: Initiators of biosynthesis of complex bacterial glycoconjugatesR01GM131627 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ALLEN, KAREN N. · 2019 to 2025
$3.1M
Structural and functional characterization of phosphoglycosyl transferases from human pathogensF32GM134576 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DODGE, GREGORY J · 2019 to 2021
$161k
NIGMS NIH HHS F32 GM134576NIGMS NIH HHS R01 GM039334NIGMS NIH HHS R01 GM131627
6 · The paper itself

Abstract

Bacterial cell surface glycoconjugates are critical for cell survival and for interactions between bacteria and their hosts. Consequently, the pathways responsible for their biosynthesis have untapped potential as therapeutic targets. The localization of many glycoconjugate biosynthesis enzymes to the membrane represents a significant challenge for expressing, purifying, and characterizing these enzymes. Here, we leverage cutting-edge methods to stabilize, purify, and structurally characterize WbaP, a phosphoglycosyl transferase (PGT) from

Identifiers

PMID37398332
PMCPMC10312794
OpenAlexW4381053482

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.