Evidence map›Paper›PMID 37398300›Full record

ArticlebioRxiv : the preprint server for biology2023

A single DPE core promoter motif contributes to

Anna Sloutskin, Dekel Itzhak, Georg Vogler, Diana Ideses, Hadar Alter, Hadar Shachar, Tirza Doniger, Manfred Frasch, Rolf Bodmer, Sascha H Duttke and 1 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Anna SloutskinThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Dekel ItzhakThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Georg VoglerDevelopment, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Diana IdesesThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Hadar AlterThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Hadar ShacharThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Tirza DonigerThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Manfred FraschDivision of Developmental Biology, Department of Biology, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany.
Rolf BodmerDevelopment, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Sascha H DuttkeSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
Tamar Juven-GershonThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Bar-Ilan University · ILSanford Burnham Prebys Medical Discovery Institute · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEWashington State University · US

Funding

HEART DEVELOPMENT IN DROSOPHILAR01HL054732 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BODMER, ROLF · 1995 to 2024
$11.3M
Exploiting Natural Genetic and Organismic Variation to Identify the DNA Motifs Regulating TranscriptionR00GM135515 · NIGMS · WASHINGTON STATE UNIVERSITY · PI DUTTKE, SASCHA H. · 2022 to 2024
$747k
NHLBI NIH HHS R01 HL054732NIGMS NIH HHS R00 GM135515
6 · The paper itself

Abstract

Transcription is initiated at the core promoter, which confers specific functions depending on the unique combination of core promoter elements. The downstream core promoter element (DPE) is found in many genes related to heart and mesodermal development. However, the function of these core promoter elements has thus far been studied primarily in isolated,

Indexed as

Core PromoterDPEDrosophilaGene Expressionheart developmentnascent transcriptionRNA Polymerase II transcription

Identifiers

PMID37398300
PMCPMC10312617
OpenAlexW4380322106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.