Evidence map›Paper›PMID 37398288›Full record

ArticlebioRxiv : the preprint server for biology2023

Mapping the genomic landscape of multidrug resistance in

Sachel Mok, Tomas Yeo, Davin Hong, Melanie J Shears, Leila S Ross, Kurt E Ward, Satish K Dhingra, Mariko Kanai, Jessica L Bridgford, Abhai K Tripathi and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 2 countries.

Sachel MokDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY.
Tomas YeoDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY.
Davin HongDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY.
Melanie J ShearsDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Leila S RossDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY.
Kurt E WardDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY.
Satish K DhingraDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY.
Mariko KanaiDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY.
Jessica L BridgfordDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY.
Abhai K TripathiDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Godfree MlamboDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Anna Y BurkhardDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY.
Kate J FairhurstDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY.
Eva Gil-IturbeDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Heekuk ParkDivision of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
Felix D RozenbergDivision of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
Jonathan KimDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.
Filippo ManciaDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.
Matthias QuickDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Anne-Catrin UhlemannCenter for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY.
Photini SinnisDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
David A FidockDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY.
Columbia University Irving Medical Center · USJohns Hopkins University · USNanyang Technological University · SG

Funding

Role of pfcrt in chloroquine resistance in P. falciparumR01AI050234 · NIAID · YESHIVA UNIVERSITY · PI FIDOCK, DAVID A · 2001 to 2015
$5.7M
Leveraging PfCRT Structure to Discern Function and Predict Emergence of Drug-Resistant MalariaR01AI147628 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock, Filippo Mancia · 2019 to 2026
$5.1M
Defining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug ResistanceR37AI050234 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2018 to 2026
$4.4M
Defining P. falciparum resistance to artemisinin-based combination therapiesR01AI109023 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDOCK, DAVID A · 2014 to 2025
$4.4M
Elucidating the molecular basis of piperaquine resistance in Plasmodium falciparumR01AI124678 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2016 to 2026
$4.3M
The Skin Phase of Malaria Infection (Sharon Patray Diversity Supplement)R01AI132359 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SINNIS, PHOTINI · 2017 to 2021
$2.7M
Deciphering the role of Plasmodium falciparum plasmepsin 2/3 amplifications in mutant pfcrt-driven piperaquine resistanceR21AI159558 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDOCK, DAVID A · 2021 to 2022
$446k
NIAID NIH HHS R01 AI050234NIAID NIH HHS R01 AI109023NIAID NIH HHS R01 AI124678NIAID NIH HHS R01 AI132359NIAID NIH HHS R01 AI147628NIAID NIH HHS R21 AI159558NIAID NIH HHS R37 AI050234
6 · The paper itself

Abstract

Drug-resistant

Identifiers

PMID37398288
PMCPMC10312498
OpenAlexW4379285209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.