Evidence map›Paper›PMID 37398278›Full record

ArticlemedRxiv : the preprint server for health sciences2024

HIV-1 latency reversal agent boosting is not limited by opioid use.

Tyler Lilie, Jennifer Bouzy, Archana Asundi, Jessica Taylor, Samantha Roche, Alex Olson, Kendyll Coxen, Heather Corry, Hannah Jordan, Kiera Clayton and 2 more

Open access · greenAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Tyler LilieBrigham and Women's Hospital, Boston, MA, USA.
Jennifer BouzyBrigham and Women's Hospital, Boston, MA, USA.
Archana AsundiDepartment of Medicine, Boston University School of Medicine & Boston Medical Center, Boston, MA USA.
Jessica TaylorDepartment of Medicine, Boston University School of Medicine & Boston Medical Center, Boston, MA USA.
Samantha RocheDepartment of Medicine, Boston University School of Medicine & Boston Medical Center, Boston, MA USA.
Alex OlsonDepartment of Medicine, Boston University School of Medicine & Boston Medical Center, Boston, MA USA.
Kendyll CoxenBrigham and Women's Hospital, Boston, MA, USA.
Heather CorryBrigham and Women's Hospital, Boston, MA, USA.
Hannah JordanBrigham and Women's Hospital, Boston, MA, USA.
Kiera ClaytonDepartment of Pathology, University of Massachusetts T.H. Chan School of Medicine, Worcester, MA, USA.
Nina LinDepartment of Medicine, Boston University School of Medicine & Boston Medical Center, Boston, MA USA.
Athe TsibrisBrigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-2681-3216
Brigham and Women's Hospital · USBoston University · USUniversity of Massachusetts Chan Medical School · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH, DEBBIE M. CHENG · 1998 to 2026
$51.7M
The effects of opioid use on HIV-1 reservoir dynamicsR61DA047038 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI LIN, NINA H., TSIBRIS, ATHE M. · 2018 to 2020
$3.2M
The effects of opioid use on HIV-1 reservoir dynamicsR33DA047038 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI SAGAR, MANISH, TSIBRIS, ATHE M. · 2022 to 2023
$1.8M
NCATS NIH HHS UL1 TR002541NIAID NIH HHS P30 AI042853NIAID NIH HHS P30 AI060354NIDA NIH HHS R33 DA047038NIDA NIH HHS R61 DA047038
6 · The paper itself

Abstract

The opioid epidemic may impact the HIV-1 reservoir and its reversal from latency in virally suppressed people with HIV (PWH). We studied forty-seven PWH and observed that lowering the concentration of HIV-1 latency reversal agents (LRA), used in combination with small molecules that do not reverse latency, synergistically increases the magnitude of HIV-1 re-activation

Identifiers

PMID37398278
PMCPMC10312897
OpenAlexW4379285009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.