Evidence map›Paper›PMID 37398269›Full record

ArticlebioRxiv : the preprint server for biology2023

Glaucoma-associated Optineurin mutations increase transmitophagy in a vertebrate optic nerve.

Yaeram Jeong, Chung-Ha O Davis, Aaron M Muscarella, Viraj Deshpande, Keun-Young Kim, Mark H Ellisman, Nicholas Marsh-Armstrong

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yaeram JeongDepartment of Ophthalmology and Vision Science, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Chung-Ha O DavisNeurosciences Program, Stanford University, Stanford, CA 94305, USA.
Aaron M MuscarellaNational Center for Microscopy and Imaging Research, Center for Research in Biological Systems, Department of Neurosciences, University of California San Diego School of Medicine, La Jolla, CA 92093, USA.
Viraj DeshpandeDepartment of Ophthalmology and Vision Science, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Keun-Young KimNational Center for Microscopy and Imaging Research, Center for Research in Biological Systems, Department of Neurosciences, University of California San Diego School of Medicine, La Jolla, CA 92093, USA.
Mark H EllismanNational Center for Microscopy and Imaging Research, Center for Research in Biological Systems, Department of Neurosciences, University of California San Diego School of Medicine, La Jolla, CA 92093, USA.
Nicholas Marsh-ArmstrongDepartment of Ophthalmology and Vision Science, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
University of California, Davis · USUniversity of California San Diego · USStanford University · US

Funding

VISION RESEARCH CORE GRANTP30EY012576 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI W MARTIN USREY · 1999 to 2026
$18.9M
National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination ResourceU24NS120055 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2021 to 2025
$5.4M
Support of and Extensions to the Cell Image LibraryR01GM082949 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2007 to 2019
$4.1M
Optic nerve head glymphatics and debris clearance in glaucomaR01EY029087 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MARSH-ARMSTRONG, NICHOLAS R · 2018 to 2022
$2.8M
Axonal mitochondria degradation as the Achilles heel of retinal ganglion cellsR01EY026471 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MARSH-ARMSTRONG, NICHOLAS R, ZACK, DONALD J. · 2016 to 2020
$2.2M
FEI TITAN HALO 300kV INTERMEDIATE VOLTAGE ELECTRON MICROSCOPES10OD021784 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2017 to 2017
$1.9M
NEI NIH HHS P30 EY012576NEI NIH HHS R01 EY026471NEI NIH HHS R01 EY029087NIGMS NIH HHS R01 GM082949NIH HHS S10 OD021784NINDS NIH HHS U24 NS120055
6 · The paper itself

Abstract

We previously described a process referred to as transmitophagy where mitochondria shed by retinal ganglion cell (RGC) axons are transferred to and degraded by surrounding astrocytes in the optic nerve head of mice. Since the mitophagy receptor Optineurin (OPTN) is one of few large-effect glaucoma genes and axonal damage occurs at the optic nerve head in glaucoma, here we explored whether OPTN mutations perturb transmitophagy. Live-imaging of

Indexed as

autophagyaxonal mitochondriaexophersglaucomamitophagyOPTNtransmitophagy

Identifiers

PMID37398269
PMCPMC10312487
OpenAlexW4379106433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.