Evidence map›Paper›PMID 37398254›Full record

ArticlebioRxiv : the preprint server for biology2023

Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism.

Avrin Ghanaeian, Sumita Majhi, Caitie L McCaffrey, Babak Nami, Corbin S Black, Shun Kai Yang, Thibault Legal, Ophelia Papoulas, Martyna Janowska, Melissa Valente-Paterno and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Avrin GhanaeianDepartment of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, McGill University, Québec, Canada.
Sumita MajhiLaboratory of Cytoskeleton and Cilia Biology, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093, Warsaw, Poland.
Caitie L McCaffreyDepartment of Molecular Biosciences, Center for Systems and Synthetic Biology, University of Texas, Austin, United States.
Babak NamiGenetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.
Corbin S BlackDepartment of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, McGill University, Québec, Canada.
Shun Kai YangDepartment of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, McGill University, Québec, Canada.
Thibault LegalDepartment of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, McGill University, Québec, Canada.
Ophelia PapoulasDepartment of Molecular Biosciences, Center for Systems and Synthetic Biology, University of Texas, Austin, United States.
Martyna JanowskaLaboratory of Cytoskeleton and Cilia Biology, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093, Warsaw, Poland.
Melissa Valente-PaternoDepartment of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, McGill University, Québec, Canada.
Edward M MarcotteDepartment of Molecular Biosciences, Center for Systems and Synthetic Biology, University of Texas, Austin, United States.
Dorota WlogaLaboratory of Cytoskeleton and Cilia Biology, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093, Warsaw, Poland.
Khanh Huy BuiDepartment of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, McGill University, Québec, Canada.
McGill University · CAInstytut Biologii Doświadczalnej im. Marcelego Nenckiego · PLThe University of Texas at Austin · USHospital for Sick Children · CA

Funding

Mapping the CPLANE interactome, an extensive protein interaction network underlying human ciliopathiesR01HD085901 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI EDWARD M MARCOTTE, John B Wallingford · 2016 to 2026
$6.2M
NICHD NIH HHS R01 HD085901
6 · The paper itself

Abstract

Cilia are hairlike protrusions that project from the surface of eukaryotic cells and play key roles in cell signaling and motility. Ciliary motility is regulated by the conserved nexin-dynein regulatory complex (N-DRC), which links adjacent doublet microtubules and regulates and coordinates the activity of outer doublet complexes. Despite its critical role in cilia motility, the assembly and molecular basis of the regulatory mechanism are poorly understood. Here, utilizing cryo-electron microscopy in conjunction with biochemical cross-linking and integrative modeling, we localized 12 DRC subunits in the N-DRC structure of

Identifiers

PMID37398254
PMCPMC10312493
OpenAlexW4378978379

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.