Evidence map›Paper›PMID 37398232›Full record

ArticlebioRxiv : the preprint server for biology2024

Dendritic excitations govern back-propagation via a spike-rate accelerometer.

Pojeong Park, David Wong-Campos, Daniel G Itkis, Byung Hun Lee, Yitong Qi, Hunter Davis, Benjamin Antin, Amol Pasarkar, Jonathan B Grimm, Sarah E Plutkis and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Pojeong ParkDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-5574-6104
David Wong-CamposDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Daniel G ItkisDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Byung Hun LeeDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Yitong QiDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Hunter DavisDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Benjamin AntinDepartments of Statistics and Neuroscience, Columbia University, New York, NY, USA.ORCID 0000-0002-3361-985X
Amol PasarkarDepartments of Statistics and Neuroscience, Columbia University, New York, NY, USA.
Jonathan B GrimmJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Sarah E PlutkisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Katie L HollandJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0009-0007-1183-195X
Liam PaninskiDepartments of Statistics and Neuroscience, Columbia University, New York, NY, USA.
Luke D LavisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-0789-6343
Adam E CohenDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-8699-2404
Harvard University · USHoward Hughes Medical Institute · USColumbia University · US

Funding

Two-Photon All-Optical Electrophysiology in Behaving MiceRF1NS126043 · NINDS · HARVARD UNIVERSITY · PI COHEN, ADAM EZRA · 2022 to 2022
$2.2M
Brain-wide correlation of single-cell firing properties to patterns of gene expressionRF1MH117042 · NIMH · HARVARD UNIVERSITY · PI COHEN, ADAM EZRA · 2018 to 2018
$1.2M
NIMH NIH HHS RF1 MH117042NINDS NIH HHS RF1 NS126043
6 · The paper itself

Abstract

Dendrites on neurons support nonlinear electrical excitations, but the computational significance of these events is not well understood. We developed molecular, optical, and analytical tools to map sub-millisecond voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons under diverse optogenetic and synaptic stimulus patterns, in acute brain slices. We observed history-dependent spike back-propagation in distal dendrites, driven by locally generated Na

Indexed as

all-optical electrophysiologydendritic biophysicsdendritic spikesplateau potentialsspike back-propagation

Identifiers

PMID37398232
PMCPMC10312650
OpenAlexW4379207672

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.