Evidence map›Paper›PMID 37398223›Full record

ArticlebioRxiv : the preprint server for biology2023

SAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition.

Nathan A McDonald, Li Tao, Meng-Qiu Dong, Kang Shen

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Nathan A McDonaldDepartment of Biology, Stanford University, Stanford, CA, USA.
Li TaoDepartment of Biology, Stanford University, Stanford, CA, USA.
Meng-Qiu DongNational Institute of Biological Sciences, Beijing, China.
Kang ShenDepartment of Biology, Stanford University, Stanford, CA, USA.
Stanford University · USHoward Hughes Medical Institute · USNational Institute of Biological Sciences, Beijing · CN

Funding

Spatial and temporal regulation of synapse formation through phase separationK99NS123233 · NINDS · STANFORD UNIVERSITY · PI MCDONALD, NATHAN · 2021 to 2022
$246k
NINDS NIH HHS K99 NS123233
6 · The paper itself

Abstract

Neuronal development orchestrates the formation of an enormous number of synapses that connect the nervous system. In developing presynapses, the core active zone structure has been found to assemble through a liquid-liquid phase separation. Here, we find that the phase separation of SYD-2/Liprin-α, a key active zone scaffold, is controlled by phosphorylation. Using phosphoproteomics, we identify the SAD-1 kinase to phosphorylate SYD-2 and a number of other substrates. Presynaptic assembly is impaired in

Identifiers

PMID37398223
PMCPMC10312667
OpenAlexW4380486761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.