Evidence map›Paper›PMID 37398218›Full record

ArticlebioRxiv : the preprint server for biology2023

Spindle Chirp and other Sleep Oscillatory Features in Young Children with Autism.

D Cumming, N Kozhemiako, A E Thurm, C A Farmer, S W Purcell, A W Buckley

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

D CummingNational Institute of Mental Health, NIH, Bethesda, MD, USA.
N KozhemiakoBrigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.
A E ThurmNational Institute of Mental Health, NIH, Bethesda, MD, USA.
C A FarmerNational Institute of Mental Health, NIH, Bethesda, MD, USA.
S W PurcellBrigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.
A W BuckleyNational Institute of Mental Health, NIH, Bethesda, MD, USA.
National Institute of Mental Health · USBrigham and Women's Hospital · US

Funding

Clinical and Behavioral Phenotyping of Autism and Related DisordersZIAMH002868 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SWEDO, SUSAN · 2009 to 2017
$17.8M
Treatment of Medical Conditions among Individuals with Autism Spectrum DisordersZIAMH002914 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SWEDO, SUSAN · 2009 to 2016
$3.8M
Leveraging National Sleep Research Resource Data for Personalized Sleep ProfilingR01HL146339 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PURCELL, SHAUN M · 2019 to 2021
$1.3M
Enhanced Measurement and Modeling of Sleep Electrophysiology to Better Understand Sleep DisparitiesR21MD012738 · NIMHD · BRIGHAM AND WOMEN'S HOSPITAL · PI PURCELL, SHAUN M · 2019 to 2020
$499k
Sleep Physiology Dynamics: Quantification, Characterization and Genetic DissectionR21HL145492 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PURCELL, SHAUN M · 2019 to 2020
$269k
Genome-wide association study of sleep spindles and related polysomnography measuresR03MH108908 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI PURCELL, SHAUN M · 2016 to 2017
$192k
Network Abnormalities in AutismR03MH108915 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HOLMES, GREGORY L. · 2016 to 2017
$155k
Intramural NIH HHS ZIA MH002868Intramural NIH HHS ZIA MH002914NHLBI NIH HHS R01 HL146339NHLBI NIH HHS R21 HL145492NIMHD NIH HHS R21 MD012738NIMH NIH HHS R03 MH108908NIMH NIH HHS R03 MH108915
6 · The paper itself

Abstract

Objectives: To determine whether spindle chirp and other sleep oscillatory features differ in young children with and without autism. Methods: Automated processing software was used to re-assess an extant set of polysomnograms representing 121 children (91 with autism [ASD], 30 typically-developing [TD]), with an age range of 1.35-8.23 years. Spindle metrics, including chirp, and slow oscillation (SO) characteristics were compared between groups. SO and fast and slow spindle (FS, SS) interactions were also investigated. Secondary analyses were performed assessing behavioural data associations, as well as exploratory cohort comparisons to children with non-autism developmental delay (DD). Results: Posterior FS and SS chirp was significantly more negative in ASD than TD. Both groups had comparable intra-spindle frequency range and variance. Frontal and central SO amplitude were decreased in ASD. In contrast to previous manual findings, no differences were detected in other spindle or SO metrics. The ASD group displayed a higher parietal coupling angle. No differences were observed in phase-frequency coupling. The DD group demonstrated lower FS chirp and higher coupling angle than TD. Parietal SS chirp was positively associated with full developmental quotient. Conclusions: For the first time spindle chirp was investigated in autism and was found to be significantly more negative than in TD in this large cohort of young children. This finding strengthens previous reports of spindle and SO abnormalities in ASD. Further investigation of spindle chirp in healthy and clinical populations across development will help elucidate the significance of this difference and better understand this novel metric.

Indexed as

autismchirpsleepslow oscillationspindle

Identifiers

PMID37398218
PMCPMC10312722
OpenAlexW4380741804

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.