ArticleResearch square2023
IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition.
Benjamin Haslund-Gourley, Kyra Woloszcuk, Jintong Hou, Jennifer Connors, Gina Cusimano, Mathew Bell, Bhavani Taramangalam, Slim Fourati, Nathan Mege, Mariana Bernui and 8 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
18 authors at 4 institutions in 1 country.
Benjamin Haslund-GourleyDrexel University College of Medicine.
Kyra WoloszcukDrexel University College of Medicine.
Jennifer ConnorsDrexel University College of Medicine.
Gina CusimanoDrexel University College of Medicine.
Mathew BellDrexel University College of Medicine.
Bhavani TaramangalamDrexel University College of Medicine.
Slim FouratiDrexel University College of Medicine.
Nathan MegeDrexel University College of Medicine.
Mariana BernuiDrexel University College of Medicine.
Drexel University · USIcahn School of Medicine at Mount Sinai · USBenaroya Research InstituteStanford University · US
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MTranslation of immunologic technologies from basic research into pre-clinical nonU19AI062629 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI COGGESHALL, KENNETH MARK · 2004 to 2023
$56.2MSystems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI Albert C Shaw · 2010 to 2026
$50.4MProject 3 - Ex vivo immune profiling of dengue viruses and vaccinesU19AI118610 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HARRIS, EVA · 2015 to 2021
$46.6MConduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4MSystems Biological Analysis of Innate and Adaptive Responses to VaccinationU19AI090023 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, LI, SHUZHAO · 2010 to 2021
$45.0MUnderstanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1MTranscriptomics to define biomarkers of neonatal vaccine immunogenicityU19AI118608 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2017 to 2021
$24.7MTollip inhibits IL-33 signaling during airway influenza virus infectionU19AI125357 · NIAID · UNIVERSITY OF ARIZONA · PI KRAFT, MONICA, VERCELLI, DONATA · 2016 to 2025
$14.7MProject 3: Mapping the Evolution of Chronic Transplant Injury in the Context of CMV InfectionU19AI128913 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REED, ELAINE F, SARWAL, MINNIE M · 2017 to 2021
$11.2MThe contribution of GPCRs to thymocyte medullary entry and central toleranceR01AI104870 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI Lauren Ilyse Richie EHRLICH · 2014 to 2026
$7.6MInvestigating the impact of helminth infection on microbioma composition and innate immunity generated during HepB vaccination. U19AI128910 · NIAID · DREXEL UNIVERSITY · PI HADDAD, ELIAS K · 2017 to 2021
$7.0MNCATS NIH HHS UL1 TR004419NIAID NIH HHS R01 AI104870NIAID NIH HHS R01 AI135803NIAID NIH HHS R01 AI145835NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI062629NIAID NIH HHS U19 AI077439NIAID NIH HHS U19 AI089992NIAID NIH HHS U19 AI090023NIAID NIH HHS U19 AI118608NIAID NIH HHS U19 AI118610NIAID NIH HHS U19 AI125357NIAID NIH HHS U19 AI128910NIAID NIH HHS U19 AI128913NIAID NIH HHS U54 AI142766
6 · The paper itselfAbstract
The glycosylation of IgG plays a critical role during human SARS-CoV-2, activating immune cells and inducing cytokine production. However, the role of IgM N-glycosylation has not been studied during acute viral infection in humans.
Indexed as
Complement DepositionCOVID-19GlycomicsIgM N-glycanImmunoglobulin MSARS-CoV-2
Identifiers
PMID37398192
PMCPMC10312960
OpenAlexW4379141280
What OpenQuestion holds
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