Evidence map›Paper›PMID 37398167›Full record

ArticlebioRxiv : the preprint server for biology2023

Host subversion of bacterial metallophore usage drives copper intoxication.

Saika Hossain, Jacqueline R Morey, Stephanie L Neville, Katherine Ganio, Jana N Radin, Javiera Norambuena, Jeffrey M Boyd, Christopher A McDevitt, Thomas E Kehl-Fie

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Saika HossainDepartment of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Jacqueline R MoreyDepartment of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Stephanie L NevilleDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, 3000, Australia.
Katherine GanioDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, 3000, Australia.
Jana N RadinDepartment of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Javiera NorambuenaDepartment of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ 08901, USA.
Jeffrey M BoydDepartment of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ 08901, USA.
Christopher A McDevittDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, 3000, Australia.
Thomas E Kehl-FieDepartment of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
University of Illinois Urbana-Champaign · USThe University of Melbourne · AURutgers, The State University of New Jersey · US

Funding

Leveraging host-imposed metal starvation to elucidate the molecular and environmental factors that dictate metal utilization by the iron/manganese superoxide dismutase superfamilyR01AI155611 · NIAID · UNIVERSITY OF IOWA · PI KEHL-FIE, THOMAS EVERETT · 2021 to 2025
$2.8M
Mechanisms of cellular respiration-dependent cell lysis and its impact on biofilm formation and disassembly in Staphylococcus aureus.R01AI139100 · NIAID · RUTGERS, THE STATE UNIV OF N.J. · PI BOYD, JEFF M · 2018 to 2022
$1.9M
Overcoming nutritional immunity: Staphylococcal adaptation to host-imposed manganese and zinc starvationR01AI118880 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KEHL-FIE, THOMAS EVERETT · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI118880NIAID NIH HHS R01 AI139100NIAID NIH HHS R01 AI155611
6 · The paper itself

Abstract

Microorganisms can acquire metal ions in metal-limited environments using small molecules called metallophores. While metals and their importers are essential, metals can also be toxic, and metallophores have limited ability to discriminate metals. The impact of the metallophore-mediated non-cognate metal uptake on bacterial metal homeostasis and pathogenesis remains to be defined. The globally significant pathogen IMPORTANCE: During infection bacteria must overcome the dual threats of metal starvation and intoxication. This work reveals that the zinc-withholding response of the host sensitizes

Identifiers

PMID37398167
PMCPMC10312489
OpenAlexW4378836594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.