Evidence map›Paper›PMID 37398155›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Do polygenic indices capture "direct" effects on child externalizing behavior? Within-family analyses in two longitudinal birth cohorts.

Peter T Tanksley, Sarah J Brislin, Jasmin Wertz, Ronald de Vlaming, Natasia S Courchesne-Krak, Travis T Mallard, Laurel L Raffington, Richard Karlsson Linnér, Philipp Koellinger, Abraham Palmer and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Peter T TanksleyDepartment of Psychology, The University of Texas at Austin, Austin, TX, USA.
Sarah J BrislinDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, Newark, NJ, USA.
Jasmin WertzDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Ronald de VlamingDepartment of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Natasia S Courchesne-KrakDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Travis T MallardDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Laurel L RaffingtonDepartment of Psychology, The University of Texas at Austin, Austin, TX, USA.
Richard Karlsson LinnérDepartment of Economics, Leiden Law School, Leiden University, the Netherlands.
Philipp KoellingerDepartment of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Abraham PalmerDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Alexandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Irwin WaldmanDepartment of Psychology, Emory University, Atlanta, GA, USA.
Danielle DickDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, Newark, NJ, USA.
Terrie E MoffittDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Avshalom CaspiDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
K Paige HardenDepartment of Psychology, The University of Texas at Austin, Austin, TX, USA.

Funding

Sequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI POLESSKAYA, OKSANA O · 2014 to 2023
$27.4M
Using the Genetic Architecture of Substance Use Disorders to Advance Gene Identification and Understanding of Pathways of RiskR01DA050721 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DANIELLE M DICK · 2020 to 2026
$3.9M
Environmental, Genetic, and Epigenetic Mechanisms for Hormonal ChangeR01HD092548 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI HARDEN, KATHRYN PAIGE · 2019 to 2023
$3.0M
Building Bridges to Allow Cross-species Translational genetics for the Study of AddictionDP1DA054394 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANCHEZ ROIGE, SANDRA · 2021 to 2025
$2.4M
Neural, genetic, and environmental indicators of treatment outcomes for adolescent substance useK23DA058808 · NIDA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Sarah Brislin · 2024 to 2026
$542k
Medical Research Council G1002190Medical Research Council MR/X010791/1NICHD NIH HHS R01 HD092548NIDA NIH HHS DP1 DA054394NIDA NIH HHS K23 DA058808NIDA NIH HHS P50 DA037844NIDA NIH HHS R01 DA050721
6 · The paper itself

Abstract

Behaviors and disorders characterized by difficulties with self-regulation, such as problematic substance use, antisocial behavior, and symptoms of attention-deficit/hyperactivity disorder (ADHD), incur high costs for individuals, families, and communities. These externalizing behaviors often appear early in the life course and can have far-reaching consequences. Researchers have long been interested in direct measurements of genetic risk for externalizing behaviors, which can be incorporated alongside other known risk factors to improve efforts at early identification and intervention. In a preregistered analysis drawing on data from the Environmental Risk (E-Risk) Longitudinal Twin Study (

Indexed as

DevelopmentDirect Genetic EffectsExternalizingPolygenic Index

Identifiers

PMID37398155
PMCPMC10312898

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.