Evidence map›Paper›PMID 37398141›Full record

ArticlebioRxiv : the preprint server for biology2023

Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice.

Adriana C Norris, Eugenia M Yazlovitskaya, Lin Zhu, Bailey S Rose, Jody C May, Katherine N Gibson-Corley, John A McLean, John M Stafford, Todd R Graham

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Adriana C NorrisDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.
Eugenia M YazlovitskayaDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.
Lin ZhuDivision of Endocrinology, Diabetes and Metabolism, Vanderbilt University Medical Center, USA.
Bailey S RoseDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Jody C MayDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Katherine N Gibson-CorleyDivision of Comparative Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John A McLeanDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
John M StaffordDivision of Endocrinology, Diabetes and Metabolism, Vanderbilt University Medical Center, USA.
Todd R GrahamDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
National Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7M
Sex-Specific Risk of Metabolic and Cardiovascular DiseaseR01HL144846 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Michael Stafford · 2019 to 2026
$4.1M
Vanderbilt Student Research Training ProgramT35DK007383 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI William Heerman · 1986 to 2026
$4.1M
Therapeutic Potential of Estrogen-Regulated Metabolism and Cardiovascular RiskR01DK109102 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STAFFORD, JOHN MICHAEL · 2016 to 2024
$3.6M
Biomedical Data Commons Workbench (BDCW)OT2OD030544 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2020 to 2024
$3.2M
Mechanisms of membrane homeostasis through protein and lipid transportR35GM144123 · NIGMS · VANDERBILT UNIVERSITY · PI TODD R GRAHAM · 2022 to 2026
$2.4M
Does Senescence Impair the Cardiovascular Benefits of Menopause Hormone Therapy?K01AG077038 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lin Zhu · 2022 to 2026
$601k
BLRD VA I01 BX002223NCI NIH HHS P30 CA068485NCRR NIH HHS S10 RR028101NEI NIH HHS P30 EY008126NHLBI NIH HHS R01 HL144846NIA NIH HHS K01 AG077038NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK109102NIDDK NIH HHS T35 DK007383NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U2C DK119886NIGMS NIH HHS R35 GM144123NIH HHS OT2 OD030544NIH HHS S10 OD021630
6 · The paper itself

Abstract

Genetic association studies have linked ATP10A and closely related type IV P-type ATPases (P4-ATPases) to insulin resistance and vascular complications, such as atherosclerosis. ATP10A translocates phosphatidylcholine and glucosylceramide across cell membranes, and these lipids or their metabolites play important roles in signal transduction pathways regulating metabolism. However, the influence of ATP10A on lipid metabolism in mice has not been explored. Here, we generated gene-specific

Identifiers

PMID37398141
PMCPMC10312798
OpenAlexW4381060572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.