Evidence map›Paper›PMID 37398140›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Apolipoprotein E moderates the association between Non-

Yuexuan Xu, Zhongxuan Sun, Erin Jonaitis, Yuetiva Deming, Qiongshi Lu, Sterling C Johnson, Corinne D Engelman

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuexuan XuDepartment of Population Health Science, School of Medicine and Public Health, University of Wisconsin-Madison.
Zhongxuan SunDepartment of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison.
Erin JonaitisWisconsin Alzheimer's Institute, University of Wisconsin-Madison.
Yuetiva DemingDepartment of Population Health Science, School of Medicine and Public Health, University of Wisconsin-Madison.
Qiongshi LuDepartment of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison.
Sterling C JohnsonDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison.
Corinne D EngelmanDepartment of Population Health Science, School of Medicine and Public Health, University of Wisconsin-Madison.
University of Wisconsin–Madison · US

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Statistical Data Enclave CoreP30AG017266 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Michal Engelman · 1999 to 2026
$17.0M
Scientific and Technical CoreP2CHD047873 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine J. Curtis · 2014 to 2026
$5.1M
Genomic and Metabolomic Data Integration in a Longitudinal Cohort at Risk for Alzheimer's DiseaseR01AG054047 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ENGELMAN, CORINNE D. · 2016 to 2020
$3.6M
Identifying Metabolomic Risk Factors in Plasma and Cerebrospinal Fluid for Alzheimer's DiseaseR21AG067092 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LU, QIONGSHI · 2020 to 2020
$375k
NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR002373NIA NIH HHS P30 AG017266NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG054047NIA NIH HHS R21 AG067092NIA NIH HHS U01 AG009740NICHD NIH HHS P2C HD047873
6 · The paper itself

Abstract

introductionVariation in preclinical cognitive decline suggests additional genetic factors related to Alzheimer's disease (e.g., a non-

methodsWe tested the PRS×

resultsWe found statistically significant PRS× DISCUSSION:

Indexed as

agingAPOEcognitioninteractionPRS

Identifiers

PMID37398140
PMCPMC10312823
OpenAlexW4380302777

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.