Evidence map›Paper›PMID 37398131›Full record

ArticlebioRxiv : the preprint server for biology2023

CRISPR-mediated germline mutagenesis for genetic sterilization of

Andrea L Smidler, Douglas G Paton, George M Church, Kevin M Esvelt, W Robert Shaw, Flaminia Catteruccia

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Andrea L SmidlerDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Douglas G PatonDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
George M ChurchDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Kevin M EsveltMedia Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
W Robert ShawDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Flaminia CatterucciaDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Harvard University · USHoward Hughes Medical Institute · USMassachusetts Institute of Technology · US

Funding

Targeting the reproductive interactome of the malaria vector Anopheles gambiaeR01AI104956 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI CATTERUCCIA, FLAMINIA · 2013 to 2017
$3.0M
Sculpting the Enteric Microbiota with CRISPR-Cas SystemsR00DK102669 · NIDDK · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESVELT, KEVIN · 2016 to 2017
$496k
Using genome engineering to study mosquito biology and combat malariaF31AI120480 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI SMIDLER, ANDREA LYNELLE · 2016 to 2018
$74k
NIAID NIH HHS F31 AI120480NIAID NIH HHS R01 AI104956NIDDK NIH HHS R00 DK102669
6 · The paper itself

Abstract

Rapid spread of insecticide resistance among anopheline mosquitoes threatens malaria elimination efforts, necessitating development of alternative vector control technologies. Sterile Insect Technique (SIT) has been successfully implemented in multiple insect pests to suppress field populations by the release of large numbers of sterile males, yet it has proven difficult to adapt to

Identifiers

PMID37398131
PMCPMC10312776
OpenAlexW4380624344

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.