Evidence map›Paper›PMID 37398095›Full record

ArticlebioRxiv : the preprint server for biology2023

Structure-based virtual screening identifies small molecule inhibitors of O-fucosyltransferase SPINDLY.

Yalikunjiang Aizezi, Hongming Zhao, Zhenzhen Zhang, Yang Bi, Qiuhua Yang, Guangshuo Guo, Hongliang Zhang, Hongwei Guo, Kai Jiang, Zhi-Yong Wang

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yalikunjiang Aizezi
Hongming Zhao
Zhenzhen ZhangORCID 0000-0003-1617-8543
Yang BiORCID 0000-0003-1270-1747
Qiuhua Yang
Guangshuo Guo
Hongliang Zhang
Hongwei GuoORCID 0000-0002-7883-9477
Kai JiangORCID 0000-0001-9901-5293
Zhi-Yong WangORCID 0000-0003-4602-3390
Carnegie Institution for Science · USSouthern University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein O-glycosylation is a nutrient-signaling mechanism that plays essential roles in maintaining cellular homeostasis across different species. In plants, SPINDLY (SPY) and SECRET AGENT (SEC) catalyze posttranslational modifications of hundreds of intracellular proteins by O-fucose and O-linked N-acetylglucosamine, respectively. SPY and SEC play overlapping roles in cellular regulation and loss of both SPY and SEC causes embryo lethality in Arabidopsis. Using structure-based virtual screening of chemical libraries followed by

Identifiers

PMID37398095
PMCPMC10312698
OpenAlexW4380609867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.