Evidence map›Paper›PMID 37398092›Full record

ArticleResearch square2023

Exploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder.

Kaiping Burrows, Leandra Figueroa-Hall, Jennifer Stewart, Ahlam Alarbi, Rayus Kuplicki, Bethany Hannafon, Chibing Tan, Victoria Risbrough, Brett McKinney, Rajagopal Ramesh and 6 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Kaiping BurrowsLaureate Institute for Brain Research.
Leandra Figueroa-HallLaureate Institute for Brain Research.
Jennifer StewartLaureate Institute for Brain Research.ORCID 0000-0003-0123-9438
Ahlam AlarbiLaureate Institute for Brain Research.
Rayus KuplickiLaureate Institute for Brain Research.ORCID 0000-0003-2954-6421
Bethany HannafonUniveristy of Tulsa.
Chibing TanUniveristy of Tulsa.
Victoria RisbroughUniveristy of Tulsa.
Brett McKinneyUniveristy of Tulsa.
Rajagopal RameshLaureate Institute for Brain Research.
Teresa VictorLaureate Institute for Brain Research.
Robin AupperleLaureate Institute for Brain Research.
Jonathan SavitzLaureate Institute for Brain Research.ORCID 0000-0001-8143-182X
Kent TeagueUniversity of Oklahoma School of Community Medicine.ORCID 0000-0002-4680-5440
Sahib KhalsaLaureate Institute for Brain Research.ORCID 0000-0003-2124-8585
Martin PaulusLaureate Institute for Brain Research, Tulsa, USA.ORCID 0000-0002-0825-3606
Laureate Institute for Brain Research · USUniversity of Tulsa · USUniversity of Oklahoma · US

Funding

Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ROBERT S. MANNEL · 2018 to 2026
$27.1M
The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Masaya Misaki · 2017 to 2026
$23.7M
A neurocomputational assay of gastrointestinal interoception in anorexia nervosaR01MH127225 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI KHALSA, SAHIB S., PAULUS, MARTIN P. · 2021 to 2025
$3.2M
Plasticity of Aversive Salience in Opioid Use DisorderR01DA050677 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI STEWART, JENNIFER LORRAINE · 2021 to 2025
$3.0M
In vivo inflammatory challenge to elucidate the role of the toll-like receptor 4 pathway in depressionK99MH126950 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI FIGUEROA-HALL, LEANDRA KALI · 2022 to 2023
$200k
NCI NIH HHS P30 CA225520NIDA NIH HHS R01 DA050677NIGMS NIH HHS P20 GM121312NIMH NIH HHS K99 MH126950NIMH NIH HHS R01 MH127225
6 · The paper itself

Abstract

Major depressive disorder (MDD) is associated with interoceptive processing dysfunctions, but the molecular mechanisms underlying this dysfunction are poorly understood. This study combined brain Neuronal-Enriched Extracellular Vesicle (NEEV) technology and serum markers of inflammation and metabolism with Functional Magnetic Resonance Imaging (fMRI) to identify the contribution of gene regulatory pathways, in particular micro-RNA (miR) 93, to interoceptive dysfunction in MDD. Individuals with MDD (

Indexed as

depressionexosomesIL-1IL-6inflammationinteroceptive awarenessTNF

Identifiers

PMID37398092
PMCPMC10312986
OpenAlexW4380881923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.