Evidence map›Paper›PMID 37398028›Full record

ArticleResearch square2023

The debranching enzyme Dbr1 regulates lariat turnover and intron splicing.

Luke Buerer, Nathaniel E Clark, Anastasia Welch, Chaorui Duan, Allison J Taggart, Brittany A Townley, Jing Wang, Rachel Soemedi, Stephen Rong, Chien-Ling Lin and 6 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Luke BuererDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.ORCID 0000-0003-1391-3370
Nathaniel E ClarkDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.
Anastasia WelchDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.
Chaorui DuanDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.
Allison J TaggartDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.
Brittany A TownleyDepartment of Pathology & Immunology, Center for Genome Integrity, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jing WangDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.
Rachel SoemediDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.
Stephen RongDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.ORCID 0000-0002-6584-1391
Chien-Ling LinDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.ORCID 0000-0002-5730-799X
Yi ZengDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA.
Adam KatolikDepartment of Chemistry, McGill University, Montreal, QC H3A 0B8, Canada.
Jonathan P StaleyDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA.
Masad J DamhaDepartment of Chemistry, McGill University, Montreal, QC H3A 0B8, Canada.ORCID 0000-0002-4458-1623
Nima MosammaparastDepartment of Pathology & Immunology, Center for Genome Integrity, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-5453-5914
William G FairbrotherDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.
John Brown University · USMcGill University · CAUniversity of Chicago · USBrown University · USWashington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Transcription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI WALTER J. CHAZIN · 2001 to 2026
$89.6M
Discovering Splicing Defects in Human GenesR01GM127472 · NIGMS · BROWN UNIVERSITY · PI William G Fairbrother · 2018 to 2026
$5.9M
A genomic approach to studying the life cycle of intron lariatsR01GM105681 · NIGMS · BROWN UNIVERSITY · PI FAIRBROTHER, WILLIAM G · 2014 to 2022
$3.7M
MECHANISM AND REGULATION OF THE DNA ALKYLATION DAMAGE RESPONSER01CA193318 · NCI · WASHINGTON UNIVERSITY · PI MOSAMMAPARAST, NIMA · 2015 to 2024
$3.6M
A SIGNALING PATHWAY SPECIFIC FOR ALKYLATION DAMAGER01CA227001 · NCI · WASHINGTON UNIVERSITY · PI MOSAMMAPARAST, NIMA · 2018 to 2022
$1.8M
Regulation of RNA processing by the novel spliceosomal protein, TTDN1, in development and cancerF31CA254143 · NCI · WASHINGTON UNIVERSITY · PI TOWNLEY, BRITTANY A · 2020 to 2022
$72k
NCI NIH HHS F31 CA254143NCI NIH HHS P01 CA092584NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA193318NCI NIH HHS R01 CA227001NIGMS NIH HHS R01 GM105681NIGMS NIH HHS R01 GM127472
6 · The paper itself

Abstract

The majority of genic transcription is intronic. Introns are removed by splicing as branched lariat RNAs which require rapid recycling. The branch site is recognized during splicing catalysis and later debranched by Dbr1 in the rate-limiting step of lariat turnover. Through generation of the first viable

Indexed as

AQRDbr1intron lariatslariat-seqRNA processingRNA splicingspliceosome

Identifiers

PMID37398028
PMCPMC10312976
OpenAlexW4380300615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.