Evidence map›Paper›PMID 37398001›Full record

ArticlebioRxiv : the preprint server for biology2023

Microglial P2Y

Anthony D Umpierre, Bohan Li, Katayoun Ayasoufi, Shunyi Zhao, Manling Xie, Grace Thyen, Benjamin Hur, Jiaying Zheng, Yue Liang, Zhaofa Wu and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 12 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Anthony D UmpierreDepartment of Neurology, Mayo Clinic, Rochester, MN 55905.
Bohan LiState Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, Peking University School of Life Sciences, Beijing, CN 100871.
Katayoun AyasoufiDepartment of Immunology, Mayo Clinic, Rochester, MN 55905.
Shunyi ZhaoDepartment of Neurology, Mayo Clinic, Rochester, MN 55905.
Manling XieDepartment of Neurology, Mayo Clinic, Rochester, MN 55905.
Grace ThyenDepartment of Neurology, Mayo Clinic, Rochester, MN 55905.
Benjamin HurMicrobiome Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905.
Jiaying ZhengDepartment of Neurology, Mayo Clinic, Rochester, MN 55905.
Yue LiangDepartment of Neurology, Mayo Clinic, Rochester, MN 55905.
Zhaofa WuState Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, Peking University School of Life Sciences, Beijing, CN 100871.
Xinzhu YuDepartment of Molecular and Integrative Physiology, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Jaeyun SungMicrobiome Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905.
Aaron J JohnsonDepartment of Neurology, Mayo Clinic, Rochester, MN 55905.
Yulong LiState Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, Peking University School of Life Sciences, Beijing, CN 100871.
Long-Jun WuDepartment of Neurology, Mayo Clinic, Rochester, MN 55905.
Mayo Clinic · USPeking University · CNMayo Clinic in Arizona · USUniversity of Illinois Urbana-Champaign · US

Funding

CD8 T cell mediated disruption of Blood Brain Barrier Tight JunctionsR01NS103212 · NINDS · MAYO CLINIC ROCHESTER · PI Aaron J Johnson · 2017 to 2026
$4.6M
The Role of Microglia in EpilepsyR01NS088627 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WU, LONG-JUN · 2014 to 2023
$3.6M
How microglia sense and regulate neuronal activity in the adult brainR35NS132326 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Long-Jun Wu · 2023 to 2026
$3.2M
Defining MHC class I restricted antigen presentation to CD8 T cells in experimental AD and Tauopathy - SupplementRF1NS122174 · NINDS · MAYO CLINIC ROCHESTER · PI JOHNSON, AARON J · 2021 to 2023
$2.0M
Microglial P2Y6 receptor calcium signaling as a core regulator of epileptogenesisK99NS126417 · NINDS · MAYO CLINIC ROCHESTER · PI UMPIERRE, ANTHONY DAVID · 2022 to 2023
$236k
NINDS NIH HHS K99 NS126417NINDS NIH HHS R01 NS088627NINDS NIH HHS R01 NS103212NINDS NIH HHS R35 NS132326NINDS NIH HHS RF1 NS122174
6 · The paper itself

Abstract

Microglial calcium signaling is rare in a baseline state but shows strong engagement during early epilepsy development. The mechanism and purpose behind microglial calcium signaling is not known. By developing an

Identifiers

PMID37398001
PMCPMC10312639
OpenAlexW4380449981

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.