Evidence map›Paper›PMID 37397971›Full record

ReviewImmunotherapy advances2023

Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective.

Shimon Sakaguchi, Ryoji Kawakami, Norihisa Mikami

Abstract readReview
In one paragraph

Review in Immunotherapy advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Regulatory T cells: From Foxp3 to tolerance-inducing therapies.The Journal of investigative dermatology · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. B cells enable autoreactive T cells to avoid suppression.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Induction of high numbers of TBMC immunology · 2025
    Article
  15. Regulatory T Cell-Based Adoptive Cell Therapy in Autoimmunity.International journal of molecular sciences · 2025
    Review
  16. Article
  17. HLA-A2 CAR/IL-2-CISC engineered Treg display robustMolecular therapy. Methods & clinical development · 2025
    Article
  18. Review
  19. Article
  20. Tolerogenic Therapies in Cardiac Transplantation.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shimon SakaguchiLaboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0001-8265-6094
Ryoji KawakamiInsitute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.ORCID https://orcid.org/0000-0003-2253-4559
Norihisa MikamiLaboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0001-6360-5363

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FoxP3-expressing regulatory T cells (Tregs), whether naturally generated in the immune system or unnaturally induced from conventional T cells (Tconvs) in the laboratory, have much therapeutic value in treating immunological diseases and establishing transplantation tolerance. Natural Tregs (nTregs) can be selectively expanded

Indexed as

adoptive cell therapyautoimmune diseaseimmune suppressionorgan transplantationregulatory T cells

Identifiers

PMID37397971
PMCPMC10309084

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.