Evidence map›Paper›PMID 37397818›Full record

ArticleJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada2022

Retrospective audit of a convenience cohort of individuals on HIV pre-exposure prophylaxis in Alberta, Canada.

Ethan Candler, Muhammad Naeem Khan, Jennifer Gratrix, Sabrina Plitt, Maria Stadnyk, Petra Smyczek, Natalie Anderson, Julia Carter, Steven Sayers, Donna Smith and 3 more

Abstract read
In one paragraph

Article in Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. The prevalence of HIV pre-exposure prophylaxis (HIV-PrEP) use and HIV-PrEP-to-need ratio in nine Canadian provinces, 2018-2021.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2025
    Article
  5. The Real-World Effectiveness of Human Immunodeficiency Virus Pre-Exposure Prophylaxis in Adults in Alberta, Canada: A Retrospective Population-Based Cohort Study.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ethan CandlerSTI Services, Alberta Health Services, Edmonton, Alberta, Canada.
Muhammad Naeem KhanHealth Protection Communicable Disease Control, Population, Public and Indigenous Health, Alberta Health Services, Edmonton, Alberta, Canada.
Jennifer GratrixSTI Services, Alberta Health Services, Edmonton, Alberta, Canada.
Sabrina PlittCentre for Communicable Disease and Infection Control, Public Health Agency of Canada, Ottawa, Ontario, Canada.
Maria StadnykSTI Services, Alberta Health Services, Edmonton, Alberta, Canada.
Petra SmyczekSTI Services, Alberta Health Services, Edmonton, Alberta, Canada.
Natalie AndersonSexual and Reproductive Health Clinics, Calgary, Alberta, Canada.
Julia CarterSexual and Reproductive Health Clinics, Calgary, Alberta, Canada.
Steven SayersDxMedical Clinics, Edmonton, Alberta, Canada.
Donna SmithRed Deer Sexual Health Clinic, Red Deer, Alberta, Canada.
Alejandra Ugarte-TorresDepartment of Medicine, Division of Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.
Caley ShukalekDepartment of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
Ameeta E SinghUniversity of Alberta, Edmonton, Alberta, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe undertook an audit of a province-wide HIV pre-exposure prophylaxis (PrEP) program in Alberta (Canada).

methodsA retrospective record review of individuals accessing PrEP in Alberta included demographics, PrEP indication(s), and reported non-prescription drug and alcohol use from March 2016 to June 2019. Hepatitis A, B, C, HIV and syphilis serology, serum creatinine, and nucleic acid amplification tests testing for chlamydia and gonorrhea were collected. Descriptive statistics, incidence, and prevalence were calculated.

resultsA total of 511 participants were seen at STI, sexual, and reproductive health clinics and private family practitioner (FP) offices; 98.4% (503) were men, median age was 34 years (IQR 28-43 years), and 89.8% (459) were gay or bisexual men who have sex with men. Non-prescription drug use was reported by 39.3% (201) and alcohol use by 55.4% (283). 94.3% (482) reported condomless anal sex in the past 6 months. Testing rates were high (>95%) for all tests except for chlamydia and gonorrhea at the first follow-up visit 89.6%; (3-4 months). There was one HIV seroconversion. The incidence of new bacterial STIs was high: chlamydia 17 cases per 100 person-years (95% CI 13.5% to 21.4%), gonorrhea 11.14 cases per 100 person-years (95% CI 8.3% to 15.0%), and syphilis 1.94 cases per 100 person-years (95% CI 0.73% to 5.12%).

conclusionsFollowing implementation of a provincial program for PrEP in Alberta, PrEP initiation and continuation was feasible in a range of settings and by both specialists and FPs.

Indexed as

evaluationHIVPrEPprevention

Identifiers

PMID37397818
PMCPMC10312220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.