Evidence map›Paper›PMID 37397681›Full record

ArticleCureus2023

Metastatic Adrenocortical Carcinoma With Chromothripsis: A Case Report and Literature Review.

Gyuhee Seong, Alexander Wu, Charles Kim, Nirmal Pathak, Elif Yakut, Zhonghua Li, Edwin Chiu

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. ISCN and Chromoanagenesis.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gyuhee SeongDepartment of Medicine, State University of New York (SUNY) Downstate Health Sciences University/Kings County Hospital Center, New York, USA.
Alexander WuDepartment of Hematology and Oncology, State University of New York (SUNY) Downstate Health Sciences University/Kings County Hospital Center, New York, USA.
Charles KimDepartment of Hematology and Oncology, State University of New York (SUNY) Downstate Health Sciences University/Kings County Hospital Center, New York, USA.
Nirmal PathakDepartment of Hematology and Oncology, State University of New York (SUNY) Downstate Health Sciences University/Kings County Hospital Center, New York, USA.
Elif YakutDepartment of Pathology, State University of New York (SUNY) Downstate Health Sciences University/Kings County Hospital Center, New York, USA.
Zhonghua LiDepartment of Pathology, State University of New York (SUNY) Downstate Health Sciences University/Kings County Hospital Center, New York, USA.
Edwin ChiuDepartment of Hematology and Oncology, State University of New York (SUNY) Downstate Health Sciences University/Kings County Hospital Center, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastatic adrenocortical carcinoma (ACC) often has a poor outcome, with a five-year survival of less than 25%. We report a rare case of metastatic ACC with a myxoid variant with chromothripsis. We review the histologic variants of ACC, including myxoid type, molecular drivers, and current and investigational therapies for adrenocortical carcinoma. We also discuss the mechanism of chromothripsis, chromothripsis in ACC tumorigenesis, and propose potential therapies targeting chromothripsis.

Indexed as

chromothripsiscomparative genomic hybridizationgenome instabilitymetastatic adrenocortical carcinomamicronucleimitotanemyxoid

Identifiers

PMID37397681
PMCPMC10313339

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.