ReviewGenes & diseases2023
Molecular basis of fluoride toxicities: Beyond benefits and implications in human disorders.
Review in Genes & diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fluoride in Raw Rice (Oryza sativa): a Global Systematic Review and Probabilistic Health Risk Assessment.Biological trace element research · 2024Pooled it
- Chronic Fluoride Exposure Disrupts Calcium-Dependent Neurodevelopmental Signalling and Brain Proteomic Architecture: Multi-Target Modulation by Naringin.Biological trace element research · 2026Article
- Eco-Friendly Low-Cost Design of Superhydrophobic Cu Mesh for Efficient Oil-Water Separation.Molecules (Basel, Switzerland) · 2026Article
- Cytotoxicity and Genotoxicity of Fluoride Toothpastes in Buccal Cells.Acta stomatologica Croatica · 2026Article
- Nanofibrous Platforms for Advanced Wound Therapeutics: Mechanisms, Materials, and Clinical Horizons.Macromolecular bioscience · 2026Review
- Benchmark Approach to Unravel Fluoride Toxicity: Liver and Kidney Disruptions in Subacutely Exposed Rats.Journal of xenobiotics · 2026Article
- Nano gold-loaded Nannochloropsis oculata attenuates fluoride-induced neural and hepatorenal toxicity by modulating the Nrf2/NF-κB axis and aquaporins.Biology direct · 2026Article
- Optimal Fluoride Concentration in Drinking Water for Preventing Dental Fluorosis and Caries in 8-12-Year-Old Children in Qingdao, China: A Restricted Cubic Spline and Spatial Epidemiological Analysis Following Rural Safe Drinking Water Interventions in Endemic Fluorosis Region.Biological trace element research · 2026Article
- Salivary Proteomic Signatures Reveal Novel Mechanistic Insights into Moderate Dental Fluorosis Pathogenesis and Oral Homeostasis Disruption.Computational and structural biotechnology journal · 2026Article
- Review
- Fluoride: Toxicity, Mechanism and Role of Bioremediation in Detoxification.Current microbiology · 2025Review
- Article
- Dehydroabietylamine exerts antitumor effects by affecting nucleotide metabolism in gastric cancer.Carcinogenesis · 2024Article
- Enhanced Anti-Bacterial Activity of Arachidonic Acid against the Cariogenic BacteriumAntibiotics (Basel, Switzerland) · 2024Article
- Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation.Journal of translational medicine · 2024Article
- Comprehensive in vitro and in ovo assessment of cytotoxicity: Unraveling the impact of sodium fluoride, xylitol, and their synergistic associations in dental products.Biomolecules & biomedicine · 2024Article
- Fluoride effect on renal and hepatic functions: A comprehensive decade review of In vitro and In vivo studies.Journal of oral biology and craniofacial researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detrimental impacts of fluoride have become a global concern for several decades. Despite its beneficial role which is restricted only in skeletal tissues, deleterious effects are also observed in soft tissues and systems. The generation of enhanced oxidative stress is the commencement of excess fluoride exposure which may lead to cell death. Fluoride causes cell death through autophagy via Beclin 1 and mTOR signaling pathways. Beside these, several organ specific anomalies through different signaling pathways have been documented. Mitochondrial dysfunction, DNA damage, autophagy and apoptosis are the damaging outcomes in case of hepatic disorders. Urinary concentration defects and cell cycle arrest have been reported in renal tissues. Abnormal immune response has been characterized in the cardiac system. Cognitive dysfunction, neurodegenerative condition and learning impairment have also been observed. Altered steroidogenesis, gametogenic abnormalities, epigenetic alterations and birth defect are the major reprotoxic conclusions. Abnormal immune responses, altered immunogenic proliferation, differentiation as well as altered ratio of immune cells are well-defined anomalies in the immune system. Though the mechanistic approach of fluoride toxicity in physiological systems is common, it follows different signaling cascades. This review emphasizes diverse signaling pathways which are the targets of overexposed fluoride.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.