Evidence map›Paper›PMID 37397508›Full record

ArticlePhotoacoustics2023

In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging.

Shuangyang Zhang, Zhichao Liang, Kaiyi Tang, Xipan Li, Xiaoming Zhang, Zongxin Mo, Jian Wu, Shixian Huang, Jiaming Liu, Zhijian Zhuang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photoacoustics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Multimodal Contrast Agents for Optoacoustic Brain Imaging in Small Animals.Frontiers in bioengineering and biotechnology · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Shuangyang ZhangSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Zhichao LiangSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Kaiyi TangSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Xipan LiSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Xiaoming ZhangSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Zongxin MoSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Jian WuSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Shixian HuangSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Jiaming LiuSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Zhijian ZhuangSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Li QiSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Wufan ChenSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) and photoacoustic tomography (PAT) offer two distinct image contrasts. To integrate these two modalities, we present a comprehensive hardware-software solution for the successive acquisition and co-registration of PAT and MRI images in in vivo animal studies. Based on commercial PAT and MRI scanners, our solution includes a 3D-printed dual-modality imaging bed, a 3-D spatial image co-registration algorithm with dual-modality markers, and a robust modality switching protocol for in vivo imaging studies. Using the proposed solution, we successfully demonstrated co-registered hybrid-contrast PAT-MRI imaging that simultaneously displays multi-scale anatomical, functional and molecular characteristics on healthy and cancerous living mice. Week-long longitudinal dual-modality imaging of tumor development reveals information on size, border, vascular pattern, blood oxygenation, and molecular probe metabolism of the tumor micro-environment at the same time. The proposed methodology holds promise for a wide range of pre-clinical research applications that benefit from the PAT-MRI dual-modality image contrast.

Indexed as

Co-registrationHardware-software solutionMagnetic resonance imagingMulti-scale characteristicsPhotoacoustic Tomography

Identifiers

PMID37397508
PMCPMC10313508

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.