Evidence map›Paper›PMID 37397440›Full record

ReviewFrontiers in neuroscience2023

Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure.

Deepa Upreti, Siara K Rouzer, Abigail Bowring, Emma Labbe, Rosaline Kumar, Rajesh C Miranda, Amanda H Mahnke

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07456579 (Assessment of Alcohol and Cannabis Use Among Pregnant Women in Slovenia and Meconium Microbiome Analysis of Positive Samples), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07456579 enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Assessment of Alcohol and Cannabis Use Among Pregnant Women in Slovenia and Meconium Microbiome Analysis of Positive Samples

TypeobservationalSponsorUniversity Medical Centre LjubljanaRan2024 to 2026Enrolled600ConditionsMicrobiome Analysis, Drug Abuse in Pregnancy, Alcohol Abuse in Pregnancy, Health Behavior, Risky
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Deepa UpretiDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University School of Medicine, Bryan, TX, United States.
Siara K RouzerDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University School of Medicine, Bryan, TX, United States.
Abigail BowringDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University School of Medicine, Bryan, TX, United States.
Emma LabbeDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University School of Medicine, Bryan, TX, United States.
Rosaline KumarDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University School of Medicine, Bryan, TX, United States.
Rajesh C MirandaDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University School of Medicine, Bryan, TX, United States.
Amanda H MahnkeDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University School of Medicine, Bryan, TX, United States.
Texas A&M University · USTexas A&M Health Science Center · US

Funding

Simultaneous prenatal alcohol and cannabinoid exposure & offspring corticostriatal neurocircuitryF32AA029866 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ROUZER, SIARA · 2022 to 2024
$200k
NIAAA NIH HHS F32 AA029866NIAAA NIH HHS L40 AA030427
6 · The paper itself

Abstract

Alcohol exposure in adulthood can result in inflammation, malnutrition, and altered gastroenteric microbiota, which may disrupt efficient nutrient extraction. Clinical and preclinical studies have documented convincingly that prenatal alcohol exposure (PAE) also results in persistent inflammation and nutrition deficiencies, though research on the impact of PAE on the enteric microbiota is in its infancy. Importantly, other neurodevelopmental disorders, including autism spectrum and attention deficit/hyperactivity disorders, have been linked to gut microbiota dysbiosis. The combined evidence from alcohol exposure in adulthood and from other neurodevelopmental disorders supports the hypothesis that gut microbiota dysbiosis is likely an etiological feature that contributes to negative developmental, including neurodevelopmental, consequences of PAE and results in fetal alcohol spectrum disorders. Here, we highlight published data that support a role for gut microbiota in healthy development and explore the implication of these studies for the role of altered microbiota in the lifelong health consequences of PAE.

Indexed as

ethanolextracellular vesiclesFASDgut-brain axisgut microbiotanon-protein-coding RNAnutrition

Identifiers

PMID37397440
PMCPMC10308314
OpenAlexW4380680914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.