Evidence map›Paper›PMID 37396824›Full record

ArticleChem2022

Unified Total Synthesis of the Limonoid Alkaloids: Strategies for the De Novo Synthesis of Highly Substituted Pyridine Scaffolds.

Alexander W Schuppe, Yannan Liu, Elsie Gonzalez-Hurtado, Yizhou Zhao, Xuefeng Jiang, Sebastian Ibarraran, David Huang, Emma Wang, Jaehoo Lee, J Patrick Loria and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Alexander W SchuppeDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.
Yannan LiuDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.
Elsie Gonzalez-HurtadoDepartment of Pathology, Immunobiology, Comparative Medicine, Yale School of Medicine, 310 Cedar Street, New Haven, Connecticut 06520, United States.
Yizhou ZhaoDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.
Xuefeng JiangCollege of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou 310018, P. R. China.
Sebastian IbarraranDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.
David HuangDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.
Emma WangDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.
Jaehoo LeeDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.
J Patrick LoriaDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.
Vishwa Deep DixitDepartment of Pathology, Immunobiology, Comparative Medicine, Yale School of Medicine, 310 Cedar Street, New Haven, Connecticut 06520, United States.
Xin LiCollege of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou 310018, P. R. China.
Timothy R NewhouseDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.
Yale University · USZhejiang University · CN

Funding

PREDOCTORAL PROGRAM IN BIOPHYSICST32GM008283 · NIGMS · YALE UNIVERSITY · PI XIONG, YONG · 1988 to 2022
$10.5M
Synthesis of Neurologically Active Small MoleculesR01GM118614 · NIGMS · YALE UNIVERSITY · PI NEWHOUSE, TIMOTHY · 2017 to 2025
$3.1M
Mechanism of catalytic regulation and active site loop motions in related protein tyrosine phosphatasesR01GM112781 · NIGMS · YALE UNIVERSITY · PI LORIA, JOSEPH P · 2015 to 2024
$2.8M
NIGMS NIH HHS R01 GM112781NIGMS NIH HHS R01 GM118614NIGMS NIH HHS T32 GM008283
6 · The paper itself

Abstract

Highly substituted pyridine scaffolds are found in many biologically active natural products and therapeutics. Accordingly, numerous complementary

Indexed as

DFTgranatumine ALimonoid alkaloidNMR computationpyridine synthesisterpenoidtotal synthesisxylogranatopyridine B

Identifiers

PMID37396824
PMCPMC10311986
OpenAlexW4300978975

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.