Evidence map›Paper›PMID 37396807›Full record

ArticleEClinicalMedicine2023

Impact of minimal residual disease standardised assessment by FDG-PET/CT in transplant-eligible patients with newly diagnosed multiple myeloma enrolled in the imaging sub-study of the FORTE trial.

Elena Zamagni, Stefania Oliva, Francesca Gay, Andrea Capra, Delia Rota-Scalabrini, Mattia D'Agostino, Angelo Belotti, Monica Galli, Manuela Racca, Renato Zambello and 21 more

Abstract read
In one paragraph

Article in EClinicalMedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. EANM guidelines on the use of [European journal of nuclear medicine and molecular imaging · 2024
    Guideline
  2. Trial
  3. Review
  4. Review
  5. Article
  6. PET in myeloma redefined: a comparative imaging study with FDG and fluorocholine PET/CT.European journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Multiple Myeloma Unpacked.Hematological oncology · 2025
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. A rational approach to functional high-risk myeloma.Hematology. American Society of Hematology. Education Program · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Elena ZamagniIRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.
Stefania OlivaDivision of Hematology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.
Francesca GayDivision of Hematology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.
Andrea CapraDivision of Hematology, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Delia Rota-ScalabriniMultidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS, Torino, Italy.
Mattia D'AgostinoDivision of Hematology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.
Angelo BelottiDepartment of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy.
Monica GalliUO Hematology, ASST Papa Giovanni XXIII, Bergamo, Italy.
Manuela RaccaNuclear Medicine Unit, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.
Renato ZambelloDepartment of Medicine (DIMED), Hematology and Clinical Immunology, Padua University, Padua, Italy.
Barbara GamberiAzienda USL - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Domenico AlbanoNuclear Medicine Department, University of Brescia and ASST Spedali Civili Brescia, Brescia, Italy.
Luca BertaminiDivision of Hematology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.
Annibale VersariNuclear Medicine Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Mariella GrassoAzienda Ospedaliera S. Croce-Carle, Cuneo, Italy.
Nicola SgherzaHematology and Stem Cell Transplantation Unit, AOU Consorziale Policlinico, Bari, Italy.
Claudia PriolaDivision of Hematology, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Francesca FioritoniOspedale Santo Spirito, Pescara, Italy.
Francesca PatriarcaHematologic Clinic and Transplant Center, University Hospital of Central Friuli, DAME, University of Udine, Udine, Italy.
Gabriella De CiccoIRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.
Tania VillanovaDivision of Hematology, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Anna PascarellaUOC Ematologia, Ospedale dell'Angelo, Venezia Mestre, Italy.
Pietro ZucchettaNuclear Medicine Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy.
Paola TacchettiIRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.
Stefano FantiNuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Katia MancusoIRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.
Simona BarbatoIRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.
Mario BoccadoroDivision of Hematology, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Pellegrino MustoHematology and Stem Cell Transplantation Unit, AOU Consorziale Policlinico, Bari, Italy.
Michele CavoIRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.
Cristina NanniNuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: 18F-FDG-PET/CT is the current standard technique to define minimal residual disease (MRD) outside the bone marrow (BM) in multiple myeloma (MM), recently standardised applying the Deauville scores (DS) to focal lesions (FS) and bone marrow uptake (BMS) and defining the complete metabolic response (CMR) as uptake below the liver background (DS <4). Methods: In this analysis, we aimed at confirming the role of CMR, and complementarity with BM multiparameter flow cytometry (MFC) at 10 Findings: At B, 93% of patients had focal lesions within the bones (FS ≥4 in 89%) and 99% increased BM uptake (BMS ≥4 in 61%). At PM, CMR was achieved in 63% of patients, which was a strong predictor for prolonged PFS in univariate analysis at landmark time PM (HR 0.40, Interpretation: We herein confirm the applicability and validity of DS criteria to define CMR and its prognostic relevance and complementarity with MFC at the BM level. Funding: Amgen, Celgene/Bristol Myers Squibb, Italian Ministry of Health (RC-2022-2773423).

Indexed as

Complete metabolic response (CMR)FDG-PET/CTMinimal residual disease (MRD)Multiparameter flow cytometry (MFC)Newly diagnosed multiple myeloma (NDMM)

Identifiers

PMID37396807
PMCPMC10314158

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.