Evidence map›Paper›PMID 37396408›Full record

ArticleAddiction neuroscience2023

The role of sex hormones in targeting stress-induced tobacco craving, stress-reactivity, and smoking with guanfacine among women who smoke.

MacKenzie R Peltier, Sherry A McKee

Open access · goldAbstract read
In one paragraph

Article in Addiction neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Exploring Gender Differences in Receipt of the 5As for Smoking Cessation for Recently Diagnosed Cancer Patients (ECOG-ACRIN EAQ171CD).Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

MacKenzie R PeltierDepartment of Psychiatry, Yale School of Medicine, 2 Church Street South, Suite 109, Yale School of Medicine, New Haven, CT 06519, USA.
Sherry A McKeeDepartment of Psychiatry, Yale School of Medicine, 2 Church Street South, Suite 109, Yale School of Medicine, New Haven, CT 06519, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale-SCORE Resource Support CoreU54AA027989 · NIAAA · YALE UNIVERSITY · PI Sherry Ann McKee · 2020 to 2026
$13.0M
Yale SCOR on Gender-Sensitive Treatment for Tobacco DependenceP50DA033945 · NIDA · YALE UNIVERSITY · PI MCKEE, SHERRY ANN · 2012 to 2017
$6.5M
Sex-Appropriate Treatment Development for Alcohol Use DisordersP01AA027473 · NIAAA · YALE UNIVERSITY · PI COSGROVE, KELLY P. · 2018 to 2019
$1.0M
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS P01 AA027473NIAAA NIH HHS U54 AA027989NIDA NIH HHS P50 DA033945
6 · The paper itself

Abstract

Women who smoke are particularly vulnerable to tobacco craving, smoking behaviors, and relapse in the context of stress when compared to men who smoke. One factor in this sex difference may be sex hormones, including estradiol and progesterone; however, smoking cessation medication trials often do not explore the impact of sex hormones on drug effects. This secondary analysis of a double-blind, placebo-controlled study explored the impact of levels of actual estradiol and progesterone on guanfacine, a noradrenergic α2a agonist, which attenuates stress-induced smoking behaviors in women. Women who smoke (

Indexed as

CigarettesEstradiolGuanfacineProgesteroneStress-reactivityTobaccoWomen

Identifiers

PMID37396408
PMCPMC10311966
OpenAlexW4362584612

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.