Evidence map›Paper›PMID 37396263›Full record

ArticleACS omega2023

Quantum Dot-DNA FRET Conjugates for Direct Analysis of Methylphosphonic Acid in Complex Media.

Steven M E Demers, Wendy W Kuhne, Ashlee R Swindle, Don D Dick, Kaitlin J Coopersmith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Steven M E DemersGlobal Security Directorate, Savannah River National Laboratory, P.O. Box A, Aiken, South Carolina 29808, United States.ORCID https://orcid.org/0000-0001-9221-3246
Wendy W KuhneGlobal Security Directorate, Savannah River National Laboratory, P.O. Box A, Aiken, South Carolina 29808, United States.
Ashlee R SwindleGlobal Security Directorate, Savannah River National Laboratory, P.O. Box A, Aiken, South Carolina 29808, United States.
Don D DickGlobal Security Directorate, Savannah River National Laboratory, P.O. Box A, Aiken, South Carolina 29808, United States.
Kaitlin J CoopersmithGlobal Security Directorate, Savannah River National Laboratory, P.O. Box A, Aiken, South Carolina 29808, United States.ORCID https://orcid.org/0000-0001-6589-8825

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid detection of nerve agents from complex matrices with minimal sample preparation is essential due to their high toxicity and bioavailability. In this work, quantum dots (QDs) were functionalized with oligonucleotide aptamers that specifically targeted a nerve agent metabolite, methylphosphonic acid (MePA). These QD-DNA bioconjugates were covalently linked to quencher molecules to form Förster resonance energy transfer (FRET) donor-acceptor pairs that quantitatively measure the presence of MePA. Using the FRET biosensor, the MePA limit of detection was 743 nM in artificial urine. A decrease in the QD lifetime was measured upon DNA binding and was recovered with MePA. The biosensor's flexible design makes it a strong candidate for the rapid detection of chemical and biological agents for deployable, in-field detectors.

Identifiers

PMID37396263
PMCPMC10308513

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.