Evidence map›Paper›PMID 37396252›Full record

ArticleACS omega2023

Synthesis and Application of Two-Photon Active Fluorescent Rhodol Dyes for Antibody Conjugation and

Dénes Szepesi Kovács, Balázs Chiovini, Dalma Müller, Estilla Zsófia Tóth, Anna Fülöp, Péter Ábrányi-Balogh, Lucia Wittner, György Várady, Ödön Farkas, Gábor Turczel and 6 more

Abstract read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Dénes Szepesi KovácsMedicinal Chemistry Research Group, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.
Balázs ChioviniFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, H-1444 Budapest, Hungary.
Dalma MüllerOncology Biomarker Research Group, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.
Estilla Zsófia TóthNational Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.
Anna FülöpFemtonics Ltd., H-1094 Budapest, Hungary.
Péter Ábrányi-BaloghMedicinal Chemistry Research Group, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.
Lucia WittnerNational Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.
György VáradyMolecular Cell Biology Research Group, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.
Ödön FarkasDepartment of Organic Chemistry, Eötvös Loránd University, H-1117 Budapest, Hungary.ORCID https://orcid.org/0000-0002-4217-0150
Gábor TurczelNMR Research Laboratory, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.ORCID https://orcid.org/0000-0002-6753-6796
Gergely KatonaFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, H-1444 Budapest, Hungary.
Balázs GyőrffyNational Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.
György Miklós KeserűMedicinal Chemistry Research Group, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.
Zoltán MucsiBrain Vision Center, H-1094 Budapest, Hungary.ORCID https://orcid.org/0000-0003-3224-8847
Balázs J RózsaFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, H-1444 Budapest, Hungary.
Ervin KovácsFemtonics Ltd., H-1094 Budapest, Hungary.ORCID https://orcid.org/0000-0002-3939-6925

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel family of julolidine-containing fluorescent rhodols equipped with a wide variety of substituents was synthesized in a versatile two-step process. The prepared compounds were fully characterized and exhibited excellent fluorescence properties for microscopy imaging. The best candidate was conjugated to the therapeutic antibody trastuzumab through a copper-free strain-promoted azide-alkyne click reaction. The rhodol-labeled antibody was successfully applied for

Identifiers

PMID37396252
PMCPMC10308389

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.